SN-6

Name: SN-6
Brand: Tocris Bioscience
SKU: 2184

Tocris Bioscience, part of Bio-Techne | Catalog # 2184

Citations (58)

COA / SDS

Selective Na+/Ca2+ exchange inhibitor (reverse mode)

Key Product Details

Description:	Selective Na⁺/Ca²⁺ exchange inhibitor (reverse mode)
Chemical Name:	2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	402.16

View Full Technical Details for SN-6

Technical Data
Citations

Biological Activity for SN-6

SN-6 is a selective Na⁺/Ca²⁺-exchange (NCX) inhibitor; displays some selectivity for NCX1. IC₅₀ values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent ⁴⁵Ca²⁺ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh receptors (IC₅₀ = 18 μM) but minimal activity against NCKX2 and various receptors and ion channels (IC₅₀ > 30 μM). Preferentially blocks Ca²⁺ influx mode and is more selective for NCX isoforms than KB-R7943 (Cat. No. 1244). Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC₅₀ = 0.63 μM).

Compound Libraries for SN-6

SN-6 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SN-6

M. Wt	402.16
Formula	C₂₀H₂₂N₂O₅S
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	415697-08-4
PubChem ID	10222761
InChi Key	ZVYIJXLMBWCGHP-UHFFFAOYSA-N
Smiles	CCOC(=O)C1CSC(CC2=CC=C(OCC3=CC=C(C=C3)[N+]([O-])=O)C=C2)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SN-6

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.22	100

Preparing Stock Solutions for SN-6

The following data is based on the product molecular weight 402.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.49 mL	12.43 mL	24.87 mL
5 mM	0.50 mL	2.49 mL	4.97 mL
10 mM	0.25 mL	1.24 mL	2.49 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for SN-6

References are publications that support the biological activity of the product.

Iwamoto Forefront of Na⁺/Ca²⁺ exchanger studies: molecular pharmacology of N⁺/Ca²⁺ exchange inhibitors. J.Pharmacol.Sci. 2004 PMID: 15359084
Iwamoto The exchanger inhibitory peptide region-dependent inhibition of Na⁺/Ca²+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative. Mol.Pharmacol. 2004 PMID: 15213295