SNC 162

Tocris Bioscience, part of Bio-Techne | Catalog # 1529

COA / SDS

Potent, selective non-peptide δ agonist

Key Product Details

Description:	Potent, selective non-peptide δ agonist
Chemical Name:	4-[(S)-[(2S,5R)-2,5-Dimethyl-4-(2-propenyl)-1-piperazinyl]phenylmethyl]-N,N-diethylbenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	419.61

View Full Technical Details for SNC 162

Technical Data
Citations

Biological Activity for SNC 162

SNC 162 is a potent and selective non-peptide δ-opioid receptor agonist (K_i = 0.63 nM). Displays > 8000-fold selectivity over μ-opioid receptors and is centrally active following systemic administration in vivo.

Technical Data for SNC 162

M. Wt	419.61
Formula	C₂₇H₃₇N₃O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	178803-51-5
PubChem ID	6604878
InChi Key	WGIDFDFAOQVAHY-UFPGJGBJSA-N
Smiles	[H][C@@](C2=CC=CC=C2)(N3C[C@@H](C)N(CC=C)C[C@@H]3C)C1=CC=C(C(N(CC)CC)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SNC 162

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. HCl	41.96	100

Preparing Stock Solutions for SNC 162

The following data is based on the product molecular weight 419.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.92 mL	23.83 mL
5 mM	0.48 mL	2.38 mL	4.77 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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Reconstitution Calculator

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References for SNC 162

References are publications that support the biological activity of the product.

Knapp Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors. J.Pharmacol.Exp.Ther. 1996 PMID: 8667189
Negus Behavioral effects of the delta-selective opioid agonist SNC80 and related compounds in rhesus monkeys. J.Pharmacol.Exp.Ther. 1998 PMID: 9655881
Calderon Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective δ agonist (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-< J.Med.Chem. 1997 PMID: 9057856