SNIPER(ER)-87

Name: SNIPER(ER)-87
Brand: Tocris Bioscience
SKU: 7120

Tocris Bioscience, part of Bio-Techne | Catalog # 7120

Citations (1)

COA / SDS

Potent and selective ERα Degrader (SNIPER)

Key Product Details

Description:	Potent and selective ERα Degrader (SNIPER)
Chemical Name:	(2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-[3-[[14-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]-12-methyl-11-oxo-3,6,9-trioxa-12-azatetradec-1-yl]oxy]benzoyl]-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)propanamide
Purity:	≥98% (HPLC)
Molecular Weight:	1044.32

View Full Technical Details for SNIPER(ER)-87

Technical Data
Citations

Biological Activity for SNIPER(ER)-87

SNIPER(ER)-87 is a potent and selective estrogen receptor α (ERα) Degrader (Specific and Nongenetic IAP-dependent Protein Erasers or SNIPER) (DC₅₀ = 3 nM). SNIPER(ER)-87 comprises the IAP binding ligand LCL 161 (Cat. No. 7178) joined by a linker to the estrogen-binding moiety 4-hydroxytamoxifen (Cat. No. 3412). The product decreases ERα levels in breast cancer cells in vitro and in mouse ovaries in vivo. SNIPER(ER)-87 also reduces ERα levels and inhibits tumor proliferation in breast cancer xenograft mouse models. ER alpha/NR3A1 antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF 5715 and MAB57151.

Technical Data for SNIPER(ER)-87

M. Wt	1044.32
Formula	C₅₉H₇₃N₅O₁₀S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2222354-91-6
PubChem ID	155563319
InChi Key	ILLYWIKUEZHTSD-RJFLEHBVSA-N
Smiles	CC/C(C1=CC=CC=C1)=C(C2=CC=C(C=C2)OCCN(C(COCCOCCOCCOC3=CC(C(C4=CSC([C@@H]5CCCN5C([C@H](C6CCCCC6)NC([C@@H](NC)C)=O)=O)=N4)=O)=CC=C3)=O)C)\C7=CC=C(C=C7)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SNIPER(ER)-87

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	104.43	100

Preparing Stock Solutions for SNIPER(ER)-87

The following data is based on the product molecular weight 1044.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.96 mL	4.79 mL	9.58 mL
5 mM	0.19 mL	0.96 mL	1.92 mL
10 mM	0.10 mL	0.48 mL	0.96 mL
50 mM	0.02 mL	0.10 mL	0.19 mL

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References for SNIPER(ER)-87

References are publications that support the biological activity of the product.

Ohoka In vivo knockdown of pathogenic proteins via specific and nongenetic inhibitor of apoptosis protein (IAP)-dependent protein erasers (SNIPERs). J.Biol.Chem. 2017 PMID: 28154167