SNS 032

Name: SNS 032
Brand: Tocris Bioscience
SKU: 4075

Tocris Bioscience, part of Bio-Techne | Catalog # 4075

Citations (8)

COA / SDS

Cdk inhibitor; potently inhibits cdk2, cdk7 and cdk9

Key Product Details

Description:	Cdk inhibitor; potently inhibits cdk2, cdk7 and cdk9
Alternative Names:	BMS-387032
Chemical Name:	N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	380.53

View Full Technical Details for SNS 032

Technical Data
Citations

Biological Activity for SNS 032

SNS 032 is a cyclin dependent kinase (cdk) inhibitor (reported IC₅₀ values are 0.004 - 0.048, 0.0045 - 0.05, 0.062 - 0.29, 0.2-0.48, 0.4 and 0.45 μM for cdk9, cdk2, cdk7, cdk1, cdk5 and cdk4, respectively). Displays no activity against 190 additional kinases (IC₅₀ >1 μM). Arrests the cell cycle at G₂/M; inhibits transcription, proliferation and colony formation, and induces apoptosis in RPMI-8226 multiple myeloma cells. Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.

Technical Data for SNS 032

M. Wt	380.53
Formula	C₁₇H₂₄N₄O₂S₂
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	345627-80-7
PubChem ID	3025986
InChi Key	OUSFTKFNBAZUKL-UHFFFAOYSA-N
Smiles	CC(C)(C)C1=CN=C(CSC2=CN=C(NC(C3CCNCC3)=O)S2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SNS 032

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	19.03	50

Preparing Stock Solutions for SNS 032

The following data is based on the product molecular weight 380.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.26 mL	26.28 mL	52.56 mL
2.5 mM	1.05 mL	5.26 mL	10.51 mL
5 mM	0.53 mL	2.63 mL	5.26 mL
25 mM	0.11 mL	0.53 mL	1.05 mL

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References for SNS 032

References are publications that support the biological activity of the product.

Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
Chen Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line. Cancer Res. 2010 PMID: 20663900
Ali SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor. Neoplasia 2007 PMID: 17534442
Conroy SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples. Cancer Chemother.Pharmacol. 2009 PMID: 19169685
Misra N-(Cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent J.Med.Chem. 2004 PMID: 15027863