Spermine tetrahydrochloride

Name: Spermine tetrahydrochloride
Brand: Tocris Bioscience
SKU: 0958

Tocris Bioscience, part of Bio-Techne | Catalog # 0958

Citations (27)

COA / SDS

Modulator at polyamine site

Key Product Details

Description:	Modulator at polyamine site
Chemical Name:	N,N'-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
Molecular Weight:	348.19

View Full Technical Details for Spermine tetrahydrochloride

Technical Data
Citations

Biological Activity for Spermine tetrahydrochloride

Spermine tetrahydrochloride is a polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects.

Technical Data for Spermine tetrahydrochloride

M. Wt	348.19
Formula	C₁₀H₂₆N₄.4HCl
Storage	Desiccate at +4°C
CAS Number	306-67-2
PubChem ID	9384
InChi Key	XLDKUDAXZWHPFH-UHFFFAOYSA-N
Smiles	NCCCNCCCCNCCCN.Cl.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Spermine tetrahydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	34.82	100

Preparing Stock Solutions for Spermine tetrahydrochloride

The following data is based on the product molecular weight 348.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.87 mL	14.36 mL	28.72 mL
5 mM	0.57 mL	2.87 mL	5.74 mL
10 mM	0.29 mL	1.44 mL	2.87 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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Reconstitution Calculator

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References for Spermine tetrahydrochloride

References are publications that support the biological activity of the product.

Munir Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Res. 1993 PMID: 8358608
Doyle and Shaw Investigation of the actions and antagonist activity of some polyamine analogues in vivo. Br.J.Pharmacol. 1998 PMID: 9641557
Johnson Modulation of channel function by polyamines. TiPS 1996 PMID: 8789355
Benveniste and Mayer Multiple effects of spermine on N-MthD.-aspartic acid receptor responses of rat cultured hippocampal neurones. J.Physiol. 1993 PMID: 8229795