Sphingosine-1-phosphate

Name: Sphingosine-1-phosphate
Brand: Tocris Bioscience
SKU: 1370

Tocris Bioscience, part of Bio-Techne | Catalog # 1370

Citations (38)

COA / SDS

Endogenous agonist at S1P1-5

Key Product Details

Description:	Endogenous agonist at S1P_1-5
Chemical Name:	(E)-D-erythro-2-amino-1-(dihydrogenphosphate)-4-octadecene-1,3-diol
Purity:	≥98% (HPLC)
Molecular Weight:	379.48

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Technical Data
Citations

Biological Activity for Sphingosine-1-phosphate

Sphingosine-1-phosphate is an endogenous second messenger involved in the control of cell proliferation and motility, and Ca²⁺ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors (S1P_1-5) and as an activator of GPR3, GPR6 and GPR12. Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase. Also activates VRAC-mediated transport of 2'3'-cyclic-GMP-AMP (cGAMP).

Technical Data for Sphingosine-1-phosphate

M. Wt	379.48
Formula	C₁₈H₃₈NO₅P
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	26993-30-6
PubChem ID	5283560
InChi Key	DUYSYHSSBDVJSM-KRWOKUGFSA-N
Smiles	O[C@H](/C=C/CCCCCCCCCCCCC)[C@@H](N)COP(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Sphingosine-1-phosphate

References are publications that support the biological activity of the product.

Lahey LRRC8A:C/E heteromeric channels are ubiquitous transporters of cGAMP. Mol.Cell. 2020 PMID: 33171122
Morstein Optical control of sphingosine-1-phosphate formation and function. Nat.Chem 2019 PMID: 31036923
van Koppen Activation of a high affinity G_i protein-coupled plasma membrane receptor by sphingosine-1-phosphate. J.Biol.Chem. 1996 PMID: 8567663
Uhlenbrock Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. Cell.Signal. 2002 PMID: 12220620
Pyne and Pyne Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors. Pharmacol.Ther. 2000 PMID: 11150592
Essler Sphingosine 1-phosphate dynamically regulates myosin light chain phosphatase activity in human endothelial cells. Cell.Signal. 2002 PMID: 11955953

Sphingosine-1-phosphate

Tocris Bioscience, part of Bio-Techne | Catalog # 1370

Key Product Details

Biological Activity for Sphingosine-1-phosphate

Technical Data for Sphingosine-1-phosphate

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Sphingosine-1-phosphate

Product Documents for Sphingosine-1-phosphate

COA

Certificate of Analysis

SDS

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