SR 11302

Name: SR 11302
Brand: Tocris Bioscience
SKU: 2476
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2476

(2)

Citations (115)

COA / SDS

AP-1 inhibitor; antitumor agent

Key Product Details

Description:	AP-1 inhibitor; antitumor agent
Chemical Name:	(E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
Purity:	≥95% (HPLC)
Molecular Weight:	376.54

View Full Technical Details for SR 11302

Technical Data
Citations / Reviews (2)

Biological Activity for SR 11302

SR 11302 is an inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo. Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC₅₀ > 1 μM for RARα, RARβ, RARγ and RXRα).

Technical Data for SR 11302

M. Wt	376.54
Formula	C₂₆H₃₂O₂
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	160162-42-5
PubChem ID	9976842
InChi Key	RQANARBNMTXCDM-DKOHIBGUSA-N
Smiles	CC(\C=C\C=C(\C=C\C1=C(C)CCCC1(C)C)C1=CC=C(C)C=C1)=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 11302

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.6	100
	ethanol	3.76	10

Preparing Stock Solutions for SR 11302

The following data is based on the product molecular weight 376.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.66 mL	13.28 mL	26.56 mL
5 mM	0.53 mL	2.66 mL	5.31 mL
10 mM	0.27 mL	1.33 mL	2.66 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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Reconstitution Calculator

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References for SR 11302

References are publications that support the biological activity of the product.

Huang Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. Proc.Natl.Acad.Sci.USA
Fanjul A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Nature 1994 PMID: 7969403
Shiohara Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro. Blood 1999 PMID: 10068679