SR 59230A hydrochloride

Name: SR 59230A hydrochloride
Brand: Tocris Bioscience
SKU: 1511

Tocris Bioscience, part of Bio-Techne | Catalog # 1511

Citations (18)

COA / SDS

Potent and selective β3 antagonist

Key Product Details

Description:	Potent and selective β₃ antagonist
Chemical Name:	1-(2-Ethylphenoxy)-3-[[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]-(2S)-2-propanol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	361.91

View Full Technical Details for SR 59230A hydrochloride

Technical Data
Citations

Biological Activity for SR 59230A hydrochloride

SR 59230A hydrochloride is a potent and selective β₃ adrenoceptor antagonist (IC₅₀ values are 40, 408 and 648 nM for β₃, β₁ and β₂ receptors respectively). Orally active in vivo.

Compound Libraries for SR 59230A hydrochloride

SR 59230A hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SR 59230A hydrochloride

M. Wt	361.91
Formula	C₂₁H₂₇NO₂.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1135278-41-9
PubChem ID	24978529
InChi Key	SHUCXUIOEAAJJL-MKSBGGEFSA-N
Smiles	O[C@@H](CN[C@H]2CCCC3=C2C=CC=C3)COC1=C(CC)C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 59230A hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	3.62	10
	DMSO	36.19	100

Preparing Stock Solutions for SR 59230A hydrochloride

The following data is based on the product molecular weight 361.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.76 mL	13.82 mL	27.63 mL
5 mM	0.55 mL	2.76 mL	5.53 mL
10 mM	0.28 mL	1.38 mL	2.76 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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References for SR 59230A hydrochloride

References are publications that support the biological activity of the product.

Mizuno Stimulation of β₃-adrenoceptors causes phosphorylation of p38 mitogen-activated protein kinase via a stimulatory G protein-dependent pathway in 3T3-L1 adipocytes. Br.J.Pharmacol. 2002 PMID: 11861323
Manara Aryloxypropanolaminotetralins are the first selective antagonists for atypical (β₃) β-adrenoceptors. Pharmacol.Comm.
Manara Functional identification of rat atypical β-adrenoceptors by the first β₃-selective antagonists, aryloxypropanolaminotetralins. Br.J.Pharmacol. 1996 PMID: 8821531