SSR 149415

Name: SSR 149415
Brand: Tocris Bioscience
SKU: 6195

Tocris Bioscience, part of Bio-Techne | Catalog # 6195

Citations (10)

COA / SDS

Potent and selective vasopressin V1B antagonist

Key Product Details

Description:	Potent and selective vasopressin V_1B antagonist
Alternative Names:	Nelivaptan
Chemical Name:	(2S,4R)-1-[(3R)-5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-(2-methoxyphenyl)-2-oxo-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	630.11

View Full Technical Details for SSR 149415

Technical Data
Citations

Biological Activity for SSR 149415

SSR 149415 is a potent and selective vasopressin V_1B antagonist (K_i values are 3.7 and 1.3 nM for native and recombinant rat V_1b receptors, respectively). Displays >70-fold selectively for rat V_1B over V_1A, V₂ oxytoxin and a range of other receptors and ion channels. Inhibits AVP-induced glucagon release in In-R1-G9 α-pancreatic cells in vitro. Inhibits stress-induced ACTH release and exhibits anxiolytic-like effects in anxiety models. Orally bioavailable.

Compound Libraries for SSR 149415

SSR 149415 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SSR 149415

M. Wt	630.11
Formula	C₃₀H₃₂ClN₃O₈S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	439687-69-1
PubChem ID	9895468
InChi Key	NJXZWIIMWNEOGJ-WEWKHQNJSA-N
Smiles	COC1=CC(OC)=C(S(=O)(N2C([C@@](C3=CC(Cl)=CC=C23)(C4=C(C=CC=C4)OC)N5C[C@@H](C[C@H]5C(N(C)C)=O)O)=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SSR 149415

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	63.01	100
	ethanol	63.01	100

Preparing Stock Solutions for SSR 149415

The following data is based on the product molecular weight 630.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.59 mL	7.94 mL	15.87 mL
5 mM	0.32 mL	1.59 mL	3.17 mL
10 mM	0.16 mL	0.79 mL	1.59 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

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References for SSR 149415

References are publications that support the biological activity of the product.

Serradeil-Le Gal An overview of SSR149415, a selective nonpeptide vasopressin V_1b receptor antagonist for the treatment of stress-related disorders. CNS Drug Rev. 2005 PMID: 15867952