ST 045849

Name: ST 045849
Brand: Tocris Bioscience
SKU: 6775

Tocris Bioscience, part of Bio-Techne | Catalog # 6775

Citations (3)

COA / SDS

O-GlcNAc transferase (OGT) inhibitor

Key Product Details

Description:	O-GlcNAc transferase (OGT) inhibitor
Chemical Name:	2-[(4-Chlorophenyl)imino]tetrahydro-4-oxo-3-(2-tricyclo[3.3.1.13,7]dec-1-ylethyl)-2H-1,3-thiazine-6-carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	446.99

View Full Technical Details for ST 045849

Technical Data
Citations

Biological Activity for ST 045849

ST 045849 is an O-GlcNAc transferase (OGT) inhibitor (IC₅₀ = 53 μM). Reduces proliferation and viability of prostate cancer cells in vitro. Depletes intracellular alanine and decreases glucose consumption by cancer cells. Decreases markers of ER stress and apoptosis in pregnant diabetic mice and reduces neural tube defects in embryos from diabetic mice.

Technical Data for ST 045849

M. Wt	446.99
Formula	C₂₃H₂₇ClN₂O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	442665-87-4
PubChem ID	4297469
InChi Key	HLPZEZRNGAXCJH-UHFFFAOYSA-N
Smiles	OC(C1CC(N(/C(S1)=N/C2=CC=C(C=C2)Cl)CCC34CC5CC(C4)CC(C3)C5)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ST 045849

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	44.7	100
	ethanol	44.7	100

Preparing Stock Solutions for ST 045849

The following data is based on the product molecular weight 446.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.19 mL	22.37 mL
5 mM	0.45 mL	2.24 mL	4.47 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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References for ST 045849

References are publications that support the biological activity of the product.

Kim Impact of protein O-GlcNAcylation on neural tube malformation in diabetic embryopathy. Sci.Rep. 2017 PMID: 28894244
Kim Versatile O-GlcNAc transferase assay for high-throughput identification of enzyme variants, substrates, and inhibitors. Bioconjug.Chem. 2014 PMID: 24866374
Itkonen Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism. Oncotarget 2016 PMID: 26824323