st-Ht31

Name: st-Ht31
Brand: Tocris Bioscience
SKU: 6286

Tocris Bioscience, part of Bio-Techne | Catalog # 6286

Citations (4)

COA / SDS

Inhibits PKA/AKAP interactions; cell permeable

Key Product Details

Description:	Inhibits PKA/AKAP interactions; cell permeable
Purity:	≥95% (HPLC)
Molecular Weight:	2798.27

View Full Technical Details for st-Ht31

Technical Data
Citations

Biological Activity for st-Ht31

st-Ht31 is a stearated form of the peptide Ht-31. Inhibits the interaction between the RII subunits of cAMP-dependent PKA and A-kinase anchoring protein (AKAP) in cell extracts. Cell permeable.

Technical Data for st-Ht31

M. Wt	2798.27
Formula	C₁₂₉H₂₁₇N₂₉O₃₉
Single Letter Sequence	DLIEEAASRIVDAVIEQVKAAGAY (Modifications: Asp-1 = N-terminal Ste)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	188425-80-1
PubChem ID	16143012
InChi Key	AHVAWKAVLPRRQS-MUBBMYIHSA-N
Smiles	CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for st-Ht31

Solubility

Soluble to 1mg/ml in 0.01M PBS (pH 7.4)

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References for st-Ht31

References are publications that support the biological activity of the product.

Stival Disruption of protein kinase A localization induces acrosomal exocytosis in capacitated mouse sperm. J.Biol.Chem. 2018 PMID: 29700114
Vijayaraghavan Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motility. J.Biol.Chem. 1997 PMID: 9030527
Carr Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. J.Biol.Chem. 1992 PMID: 1618839
Gorshkov AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons. Nat.Chem.Biol. 2017 PMID: 28192412