STING agonist C53

Name: STING agonist C53
Brand: Tocris Bioscience
SKU: 7741

Tocris Bioscience, part of Bio-Techne | Catalog # 7741

COA / SDS

Pan-polymorph STING agonist

Key Product Details

Description:	Pan-polymorph STING agonist
Chemical Name:	1-[(2-Chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-1H-indole-6-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	490.88

View Full Technical Details for STING agonist C53

Technical Data
Citations

Biological Activity for STING agonist C53

STING agonist C53 is an activator of human STING (EC₅₀ = 185 nM). It promotes the oligomerization and activation of human STING through a mechanism orthogonal to that of cGAMP. STING agonist C53 increases activity of STING variants in HEK293T cells (107%, 92% and 92% reporter activity against H232, R232 and HAQ, respectively). It induces phosphorylation of STING variants in human tumor cell lines and PBMCs. STING agonist C53 is active at human but not mouse STING. Orally bioavailable.

Compound Libraries for STING agonist C53

STING agonist C53 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for STING agonist C53

M. Wt	490.88
Formula	C₂₅H₁₉ClF₄N₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2259624-71-8
PubChem ID	137367538
InChi Key	OEBVYNULNKSONR-UHFFFAOYSA-N
Smiles	CC1(C(N(C2=CC(C(NCC3=C(C=C(C=C3F)F)F)=O)=CC=C12)CC4=C(C=CC=C4F)Cl)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for STING agonist C53

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	49.09	100

Preparing Stock Solutions for STING agonist C53

The following data is based on the product molecular weight 490.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.04 mL	10.19 mL	20.37 mL
5 mM	0.41 mL	2.04 mL	4.07 mL
10 mM	0.20 mL	1.02 mL	2.04 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

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References for STING agonist C53

References are publications that support the biological activity of the product.

Lu Activation of STING by targeting a pocket in the transmembrane domain. Nature 2022 PMID: 35388221
Pryde The discovery of potent small molecule activators of human STING. Eur.J.Med.Chem. 2021 PMID: 33038794