STO-609 acetate

Name: STO-609 acetate
Brand: Tocris Bioscience
SKU: 1551
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1551

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Citations (30)

COA / SDS

Selective CaM kinase kinase inhibitor

Key Product Details

Description:	Selective CaM kinase kinase inhibitor
Chemical Name:	7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate
Purity:	≥98% (HPLC)
Molecular Weight:	374.35

View Full Technical Details for STO-609 acetate

Technical Data
Citations / Reviews (1)

Biological Activity for STO-609 acetate

STO-609 acetate is a selective, cell-permeable inhibitor of Ca²⁺-calmodulin-dependent protein kinase kinase (K_i values are 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively); competes for the ATP-binding site. Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK.

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of STO-609 acetate is reviewed on the Chemical Probes website.

Technical Data for STO-609 acetate

M. Wt	374.35
Formula	C₁₉H₁₀N₂O₃.C₂H₄O₂
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1173022-21-3
PubChem ID	16760660
InChi Key	WNRSTFUVBWNELX-UHFFFAOYSA-N
Smiles	CC(O)=O.OC(=O)C1=C2C=CC=C3C(=O)N4C5=CC=CC=C5N=C4C(C=C1)=C23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for STO-609 acetate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	100mM NaOH	16.85	45
	DMSO	3.74	10 with sonication

Preparing Stock Solutions for STO-609 acetate

The following data is based on the product molecular weight 374.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.45 mM	5.94 mL	29.68 mL	59.36 mL
2.25 mM	1.19 mL	5.94 mL	11.87 mL
4.5 mM	0.59 mL	2.97 mL	5.94 mL
22.5 mM	0.12 mL	0.59 mL	1.19 mL

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References for STO-609 acetate

References are publications that support the biological activity of the product.

Tokumitsu STO-609, a specific inhibitor of the Ca²⁺/calmodulin-dependent protein kinase kinase. J.Biol.Chem. 2002 PMID: 11867640