STX 64

Name: STX 64
Brand: Tocris Bioscience
SKU: 7341

Tocris Bioscience, part of Bio-Techne | Catalog # 7341

Citations (1)

COA / SDS

Potent steroid sulfatase inhibitor; also inhibits carbonic anhydrase II

Key Product Details

Description:	Potent steroid sulfatase inhibitor; also inhibits carbonic anhydrase II
Chemical Name:	6,7,8,9,10,11-Hexahydro-6-oxobenzo[b]cyclohepta[d]pyran-3-yl sulfamate
Purity:	≥98% (HPLC)
Molecular Weight:	309.34

View Full Technical Details for STX 64

Technical Data
Citations

Biological Activity for STX 64

STX 64 is a potent steroid sulfatase inhibitor (IC₅₀ = 8 nM). Estrone sulfate-stimulated uterine growth and mammary tumor growth are inhibited by STX 64 in animal models. STX 64 shows inhibition of steroid sulfatase activity in peripheral blood lymphocytes, liver and tumor tissues and is active in vivo. STX 64 is also a potent inhibitor of carbonic anhydrase II (IC₅₀ = 25 nM).

Compound Libraries for STX 64

STX 64 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for STX 64

M. Wt	309.34
Formula	C₁₄H₁₅NO₅S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	288628-05-7
PubChem ID	5287541
InChi Key	DSLPMJSGSBLWRE-UHFFFAOYSA-N
Smiles	O=C1OC=2C=C(OS(=O)(=O)N)C=CC2C3=C1CCCCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for STX 64

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	30.93	100
	ethanol	3.09	10

Preparing Stock Solutions for STX 64

The following data is based on the product molecular weight 309.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.23 mL	16.16 mL	32.33 mL
5 mM	0.65 mL	3.23 mL	6.47 mL
10 mM	0.32 mL	1.62 mL	3.23 mL
50 mM	0.06 mL	0.32 mL	0.65 mL

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References for STX 64

References are publications that support the biological activity of the product.

Purohit In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE. Cancer Res. 2000 PMID: 10910045
Raobaikady Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate. J.Steroid Biochem.Mol.Biol. 2003 PMID: 12711022
Ho Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates. Biochem.Biophys.Res.Commun. 2003 PMID: 12767917