SU 3327

Name: SU 3327
Brand: Tocris Bioscience
SKU: 3607

Tocris Bioscience, part of Bio-Techne | Catalog # 3607

Citations (9)

COA / SDS

Selective JNK inhibitor

Key Product Details

Chemical Name:	5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine
Purity:	≥99%
Molecular Weight:	261.3 kDa

View Full Technical Details for SU 3327

Technical Data
Citations

Biological Activity for SU 3327

SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK) (IC₅₀ = 0.7 μM). Inhibits the protein-protein interaction between JNK and JIP (IC₅₀ = 239 nM). Displays selectivity over p38 MAPK and Akt. Restores insulin sensitivity in a mouse model of type-2 diabetes. Displays antibiotic activity against a range of bacteria including S.aureus, A.baumanni, C.difficile and M.tuberculosis.

Technical Data for SU 3327

M. Wt	261.3 kDa
Formula	C₅H₃N₅O₂S₃
Storage	Store at RT
Purity	≥99%
CAS Number	40045-50-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SU 3327

Solubility

Soluble Soluble to 100 mM in DMSO and to 10 mM in ethanol

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References for SU 3327

References are publications that support the biological activity of the product.

Lo H, Lai T, Li C, Wu W TNF-alpha induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways. Acta Pharmacol Sin, 2014;35(3):339-50. 2014 PMID: 24487964
De et al. Design, synthesis and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-jun N-terminal kinase. J.Med.Chem., 2009;52:1943 PMID: 19271755