Substance P

Name: Substance P
Brand: Tocris Bioscience
SKU: 1156
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1156

Citations (109)

COA / SDS

Sensory neuropeptide; inflammatory mediator

Key Product Details

Description:	Sensory neuropeptide; inflammatory mediator
Purity:	≥95% (HPLC)
Molecular Weight:	1347.6

View Full Technical Details for Substance P

Technical Data
Citations

Biological Activity for Substance P

Substance P is a sensory neuropeptide and inflammatory mediator. Exerts excitatory effects on central and peripheral neurons, constricts bronchioles and is involved in pain transmission.

Technical Data for Substance P

M. Wt	1347.6
Formula	C₆₃H₉₈N₁₈O₁₃S
Single Letter Sequence	RPKPQQFFGLM (Modifications: Met-11 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	33507-63-0
PubChem ID	36511
InChi Key	ADNPLDHMAVUMIW-CUZNLEPHSA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Substance P

Solubility

Soluble to 0.8mg/ml in water

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References for Substance P

References are publications that support the biological activity of the product.

Pernow Substance P. Pharmacol.Rev. 1983 PMID: 6196797
Walsh Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK₁ receptor antagonists and the role of endogenous mediators. Br.J.Pharmacol. 1995 PMID: 7541689
Andoh Substance P induction of itch-associated response mediated by cutaneous NK₁ tachykinin receptors in mice. J.Pharmacol.Exp.Ther. 1998 PMID: 9732370