Suramin hexasodium salt

Name: Suramin hexasodium salt
Brand: Tocris Bioscience
SKU: 1472
Rating: 4 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1472

(3)

Citations (35)

COA / SDS

Non-selective P2 antagonist

Key Product Details

Description:	Non-selective P2 antagonist
Chemical Name:	8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	1429.15

View Full Technical Details for Suramin hexasodium salt

Technical Data
Citations / Reviews (3)

Biological Activity for Suramin hexasodium salt

Suramin hexasodium salt is a non-selective P2 purinergic antagonist. Also blocks calmodulin binding to recognition sites and G protein coupling to G protein-coupled receptors. Increases open probability of ryanodine receptor (RyR) channels and acts as a competitive α1β2γ2 GABA_A receptor antagonist. Anticancer, antiviral and antiparasitic agent.

This product may be supplied with a high degree of hydration and some residual NaCl, the amounts of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.

Technical Data for Suramin hexasodium salt

M. Wt	1429.15
Formula	C₅₁H₃₄N₆Na₆O₂₃S₆
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	129-46-4
PubChem ID	5360
InChi Key	VAPNKLKDKUDFHK-UHFFFAOYSA-H
Smiles	[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CC1=CC=C(C=C1NC(=O)C1=CC=CC(NC(=O)NC2=CC=CC(=C2)C(=O)NC2=C(C)C=CC(=C2)C(=O)NC2=C3C(C=C(C=C3S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C2)S([O-])(=O)=O)=C1)C(=O)NC1=C2C(C=C(C=C2S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C1)S([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Suramin hexasodium salt

	Solvent	Max Conc. mg/mL
Solubility
	water	50
	DMSO	5

Preparing Stock Solutions for Suramin hexasodium salt

The following data is based on the product molecular weight 1429.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.35 mM	2.00 mL	10.00 mL	19.99 mL
1.75 mM	0.40 mL	2.00 mL	4.00 mL
3.5 mM	0.20 mL	1.00 mL	2.00 mL
17.5 mM	0.04 mL	0.20 mL	0.40 mL

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Reconstitution Calculator

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References for Suramin hexasodium salt

References are publications that support the biological activity of the product.

Luo Suramin is a novel competitive antagonist selective to α1β2γ2 GABA_A over ρ1 GABA_C receptors. Neuropharmacology. 2018 PMID: 30172846
Hill Functional regulation of the cardiac ryanodine receptor by suramin and calmodulin involves multiple binding sites. Mol.Pharmacol. 2004 PMID: 15102954
Voogd Recent research on the biological activity of suramin. Pharmacol.Rev. 1993 PMID: 8396782
Klinger Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sites. Biochem.J. 2001 PMID: 11311147
Charlton PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors. Br.J.Pharmacol. 1996 PMID: 8762097
Beindl Inhibition of receptor/G protein coupling by suramin analogues. Mol.Pharmacol. 1996 PMID: 8700151