SW 033291

Name: SW 033291
Brand: Tocris Bioscience
SKU: 5759

Tocris Bioscience, part of Bio-Techne | Catalog # 5759

Citations (1)

COA / SDS

High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation

Key Product Details

Description:	High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation
Chemical Name:	2-(Butylsulfinyl)-4-phenyl-6-(2-thienyl)-thieno[2,3-b]pyridin-3-amine
Purity:	≥98% (HPLC)
Molecular Weight:	412.59

View Full Technical Details for SW 033291

Technical Data
Citations

Biological Activity for SW 033291

SW 033291 is a high affinity 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor (K_i = 0.1 nM). Increases PGE₂ levels in A549 cells in vitro, as well as in bone marrow, colon, lung and liver in mice. Promotes hematopoiesis, recovery from DSS-induced colitis, and hepatocyte proliferation after partial hepatectomy in mice.

Compound Libraries for SW 033291

SW 033291 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for SW 033291

M. Wt	412.59
Formula	C₂₁H₂₀N₂OS₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	459147-39-8
PubChem ID	3337839
InChi Key	LCYAYKSMOVLVRL-UHFFFAOYSA-N
Smiles	NC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SW 033291

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.26	100
	ethanol	8.25	20

Preparing Stock Solutions for SW 033291

The following data is based on the product molecular weight 412.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.42 mL	12.12 mL	24.24 mL
5 mM	0.48 mL	2.42 mL	4.85 mL
10 mM	0.24 mL	1.21 mL	2.42 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for SW 033291

References are publications that support the biological activity of the product.

Zhang Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science 2015 PMID: 26068857