T 0901317

Name: T 0901317
Brand: Tocris Bioscience
SKU: 2373

Tocris Bioscience, part of Bio-Techne | Catalog # 2373

Citations (35)

COA / SDS

Potent liver X receptor (LXR) agonist; also CAR inverse agonist

Key Product Details

Description:	Potent liver X receptor (LXR) agonist; also CAR inverse agonist
Chemical Name:	N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	481.33

View Full Technical Details for T 0901317

Technical Data
Citations

Biological Activity for T 0901317

T 0901317 is a potent, high affinity liver X receptor (LXR) agonist (EC₅₀ ~ 50 nM, K_d values are 7 and 22 nM for LXR-α and LXR-β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid-β production in primary neurons in vitro. Displays an EC₅₀ of ~ 5 μM for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid. Also exhibits inverse agonist activity at constitutive androstane receptors (CAR).

Compound Libraries for T 0901317

T 0901317 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for T 0901317

M. Wt	481.33
Formula	C₁₇H₁₂F₉NO₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	293754-55-9
PubChem ID	447912
InChi Key	SGIWFELWJPNFDH-UHFFFAOYSA-N
Smiles	OC(C1=CC=C(C=C1)N(CC(F)(F)F)S(=O)(=O)C1=CC=CC=C1)(C(F)(F)F)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for T 0901317

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	48.13	100
	ethanol	48.13	100

Preparing Stock Solutions for T 0901317

The following data is based on the product molecular weight 481.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.39 mL	20.78 mL
5 mM	0.42 mL	2.08 mL	4.16 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for T 0901317

References are publications that support the biological activity of the product.

Kanno T0901317, a potent LXR agonist, is an inverse agonist of CAR. J.Toxicol.Sci. 2013 PMID: 23665929
Mitro The nuclear receptor LXR is a glucose sensor. Nature Lett.
Koldamova The liver X receptor ligand T0901317 decreases amyloid β production in vitro and in a mouse model of Alzheimer's disease. J.Biol.Chem. 2005 PMID: 15557325
Houck T0901317 is a dual LXR/FXR agonist. Mol.Gen.Metab.
Repa Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 2000 PMID: 10968783