T 3364366

Name: T 3364366
Brand: Tocris Bioscience
SKU: 6106

Tocris Bioscience, part of Bio-Techne | Catalog # 6106

Citations (1)

COA / SDS

Potent and reversible fatty acid desaturase 1 inhibitor; orally bioavailable

Key Product Details

Description:	Potent and reversible fatty acid desaturase 1 inhibitor; orally bioavailable
Chemical Name:	N-[2-[[3,4-Dihydro-4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]thieno[3,4-d]pyrimidin-2-yl]thio]ethyl]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	443.46

View Full Technical Details for T 3364366

Technical Data
Citations

Biological Activity for T 3364366

T 3364366 is a potent and reversible fatty acid desaturase 1 (FADS1; Δ⁵ desaturase) inhibitor (IC₅₀ values are 1.9 nM and 2.1 nM in human and rat hepatocyte cell lines, respectively). Exhibits >300 fold selectivity for FADS1 over FADS2 (Δ⁶ desaturase). Inhibits arachidonic acid production in rat and human hepatocyte cell lines. Orally bioavailable.

Compound Libraries for T 3364366

T 3364366 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for T 3364366

M. Wt	443.46
Formula	C₁₈H₁₆F₃N₃O₃S₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1356354-09-0
PubChem ID	86685411
InChi Key	BVRXQXNVDLUWMV-UHFFFAOYSA-N
Smiles	CC(NCCSC1=NC2=CSC=C2C(N1C3=CC=C(C=C3)OCC(F)(F)F)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for T 3364366

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.35	100

Preparing Stock Solutions for T 3364366

The following data is based on the product molecular weight 443.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.25 mL	11.27 mL	22.55 mL
5 mM	0.45 mL	2.25 mL	4.51 mL
10 mM	0.23 mL	1.13 mL	2.25 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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References for T 3364366

References are publications that support the biological activity of the product.

Miyahisa T-3364366 targets the desaturase domain of delta-5 desaturase with nanomolar potency and a multihour residence time. ACS Med.Chem.Lett. 2016 PMID: 27660693