t-TUCB

Name: t-TUCB
Brand: Tocris Bioscience
SKU: 6757

Tocris Bioscience, part of Bio-Techne | Catalog # 6757

COA / SDS

Potent soluble epoxide hydrolase (sEH) Inhibitor; anti-inflammatory and antinociceptive

Key Product Details

Description:	Potent soluble epoxide hydrolase (sEH) Inhibitor; anti-inflammatory and antinociceptive
Chemical Name:	4-[[trans-4-[[[[4-(Trifluoromethoxy)phenyl]amino]carbonyl]amino]cyclohexyl]oxy]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	438.4

View Full Technical Details for t-TUCB

Technical Data
Citations

Biological Activity for t-TUCB

t-TUCB is a potent soluble epoxide hydrolase (sEH) Inhibitor (IC₅₀ = 0.9 nM). Enhances hepatic eNOS phosphorylation and NO release. Exhibits antihypertensive and cardioprotective actions in cirrhotic rat models. Suppress the activation of HSCs and reduce hepatic fibrosis through inhibition of NF-κB/IκBα signaling. Anti-inflammatory and antinociceptive.

Technical Data for t-TUCB

M. Wt	438.4
Formula	C₂₁H₂₁F₃N₂O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	948304-40-3
PubChem ID	16756850
InChi Key	XDVFKCZZXOGEMN-UHFFFAOYSA-N
Smiles	OC(C1=CC=C(C=C1)O[C@H]2CC[C@H](NC(NC3=CC=C(C=C3)OC(F)(F)F)=O)CC2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for t-TUCB

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.84	100

Preparing Stock Solutions for t-TUCB

The following data is based on the product molecular weight 438.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.41 mL	22.81 mL
5 mM	0.46 mL	2.28 mL	4.56 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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Reconstitution Calculator

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References for t-TUCB

References are publications that support the biological activity of the product.

Deng Inhibition of soluble epoxide hydrolase lowers portal hypertension in cirrhotic rats by ameliorating endothelial dysfunction and liver fibrosis. Prostaglandins Other Lipid Mediat. 2017 PMID: 28822809
Hwang Orally bioavailable potent soluble epoxide hydrolase inhibitors. J.Med.Chem. 2007 PMID: 17616115