TAK 165

Tocris Bioscience, part of Bio-Techne | Catalog # 3599

COA / SDS

Potent and selective ErbB2 inhibitor

Key Product Details

Chemical Name:	1-[4-[4-[[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole
Purity:	≥99%
Molecular Weight:	468.47 kDa

View Full Technical Details for TAK 165

Technical Data
Citations

Biological Activity for TAK 165

TAK 165 is a potent, irreversible human epithelial growth factor receptor 2 (ErbB2) inhibitor (IC₅₀ = 6 nM) that displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC₅₀ = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo.

Technical Data for TAK 165

M. Wt	468.47 kDa
Formula	C₂₅H₂₃F₃N₄O₂
Storage	Store at +4°C
Purity	≥99%
CAS Number	366017-09-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TAK 165

Solubility

Soluble Soluble to 75 mM in DMSO

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for TAK 165

References are publications that support the biological activity of the product.

Sridhar et al. Inhibitors of epidermal-growth-factor receptors: a review of clinical research with a focus on non-small-cell lung cancer. Lancet Oncol., 2003;4:397 PMID: 12850190
Spector et al. Small molecule HER-2 tyrosine kinase inhibitors. Breast Cancer Res., 2007;9:205