TAK 779

Name: TAK 779
Brand: Tocris Bioscience
SKU: 4340

Tocris Bioscience, part of Bio-Techne | Catalog # 4340

COA / SDS

Potent and selective CCR5 and CCR2 chemokine receptor antagonist

Key Product Details

Description:	Potent and selective CCR5 and CCR2 chemokine receptor antagonist
Chemical Name:	N-[[4-[[[6,7-Dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N,N-dimethyl-2H-pyran-4-aminium chloride
Purity:	≥98% (HPLC)
Molecular Weight:	531.13

View Full Technical Details for TAK 779

Technical Data
Citations

Biological Activity for TAK 779

TAK 779 is a potent and selective CCR5 and CCR2 chemokine receptor antagonist (IC₅₀ values = 1 nM and 27 nM, respectively). TAK 779 blocks the binding of macrophage inflammatory protein 1α and 1β to CHO cells (IC₅₀ = 1 nM) and inhibits replication of R5 HIV-1 at 1.6-3.7 nM. In animal models, TAK 779 protects against ischemic brain injury and prevents development of asthma features.

Technical Data for TAK 779

M. Wt	531.13
Formula	C₃₃H₃₉N₂O₂.Cl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	229005-80-5
PubChem ID	183789
InChi Key	VDALIBWXVQVFGZ-UHFFFAOYSA-N
Smiles	CC1=CC=C(C2=CC(C=C(C(NC3=CC=C(C[N+](C)(C)C4CCOCC4)C=C3)=O)CCC5)=C5C=C2)C=C1.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TAK 779

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	5.31	10
	DMSO	2.66	5

Preparing Stock Solutions for TAK 779

The following data is based on the product molecular weight 531.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.83 mL	94.14 mL	188.28 mL
0.5 mM	3.77 mL	18.83 mL	37.66 mL
1 mM	1.88 mL	9.41 mL	18.83 mL
5 mM	0.38 mL	1.88 mL	3.77 mL

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References for TAK 779

References are publications that support the biological activity of the product.

Suzaki A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammation. Eur.Respir.J. 2008 PMID: 18094012
Takami TAK-779, a nonpeptide CC chemokine receptor antagonist, protects the brain against focal cerebral ischemia in mice. J.Cereb.Blood Flow Metab. 2002 PMID: 12142563
Baba A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc.Natl.Acad.Sci.U.S.A. 1999 PMID: 10318947