TAK 960 hydrochloride

Name: TAK 960 hydrochloride
Brand: Tocris Bioscience
SKU: 5403

Tocris Bioscience, part of Bio-Techne | Catalog # 5403

Citations (1)

COA / SDS

Potent and selective PLK1 inhibitor

Key Product Details

Chemical Name:	4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)benzamide hydrochloride
Purity:	≥98%

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Technical Data
Citations

Biological Activity for TAK 960 hydrochloride

TAK 960 hydrochloride is a potent PLK1 inhibitor (IC₅₀ values are 0.8, 16.9 and 50.2 nM for PLK1, PLK2 and PLK3 respectively). Exhibits >20-fold selectivity for PLK1 over FAK, MLCK and FES, and has minimal activity against a panel of 282 other kinases. Inhibits proliferation of a range of cancer cell lines in vitro and inhibits tumor growth of multiple human cancer cell xenografts in vivo. Orally bioavailable.

Technical Data for TAK 960 hydrochloride

Formula	C₂₇H₃₄F₃N₇O₃.HCl
Storage	Store at -20°C
Purity	≥98%
CAS Number	2108449-45-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TAK 960 hydrochloride

Solubility

Soluble Soluble to 100 mM in DMSO

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References for TAK 960 hydrochloride

References are publications that support the biological activity of the product.

Hikichi et al. TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimens. Mol.Cancer Ther., 2012;11:700 PMID: 22188812
Nie et al. Discovery of TAK-960: an orally available small molecule inhibitor of polo-like kinase 1 (PLK1). Bioorg.Med.Chem.Lett., 2013;23:3662 PMID: 23664874

TAK 960 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5403

Key Product Details

Biological Activity for TAK 960 hydrochloride

Technical Data for TAK 960 hydrochloride

Solubility for TAK 960 hydrochloride

Dilution Calculator

Reconstitution Calculator

References for TAK 960 hydrochloride

Product Documents for TAK 960 hydrochloride

COA

Certificate of Analysis

SDS

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