Talabostat mesylate

Name: Talabostat mesylate
Brand: Tocris Bioscience
SKU: 3719

Tocris Bioscience, part of Bio-Techne | Catalog # 3719

Citations (7)

COA / SDS

Potent DPP IV inhibitor; activates NLRP1b inflammasome

Key Product Details

Chemical Name:	B-[(2R)-1-[(2S)-2-Amino-3-methyl-1-oxobutyl]-2-pyrrolidinyl]boronic acid methanesulfonate
Purity:	≥98%

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Technical Data
Citations

Biological Activity for Talabostat mesylate

Talabostat mesylate is a potent DPP IV inhibitor (IC₅₀ values are <4, 4, 11, 310 and 560 nM at DPP4, DPP8, DPP9, DPP7 and FAP, respectively). Activates the inflammasome sensor protein NLRP1b and selectively triggers pyroptosis in monocytes and macrophages. Induces immune-mediated tumor regression in multiple mouse models of cancer. Orally bioavailable.

Technical Data for Talabostat mesylate

Formula	C₉H₁₉BN₂O₃.CH₃SO₃H
Storage	Store at -20°C
Purity	≥98%
CAS Number	150080-09-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Talabostat mesylate

Solubility

Soluble Soluble to 100 mM in water and to 50 mM in DMSO

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References for Talabostat mesylate

References are publications that support the biological activity of the product.

Okondo MC, Johnson DC, Sridharan R et al. DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis. Nat. Chem. Biol. 2016-11-07 PMID: 27820798
Okondo et al. Inhibition of Dpp8/9 activates the Nlrp1b inflammasome. Cell Chem.Biol., 2018;25:262 PMID: 29396289

Talabostat mesylate

Tocris Bioscience, part of Bio-Techne | Catalog # 3719

Key Product Details

Biological Activity for Talabostat mesylate

Technical Data for Talabostat mesylate

Solubility for Talabostat mesylate

Dilution Calculator

Reconstitution Calculator

References for Talabostat mesylate

Product Documents for Talabostat mesylate

COA

Certificate of Analysis

SDS

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