Talampanel

Name: Talampanel
Brand: Tocris Bioscience
SKU: 5032

Tocris Bioscience, part of Bio-Techne | Catalog # 5032

Citations (2)

COA / SDS

Non-competitive non-NMDA iGluR antagonist

Key Product Details

Description:	Non-competitive non-NMDA iGluR antagonist
Alternative Names:	GYKI 53773,LY 300164
Chemical Name:	(8R)-7-Acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
Purity:	≥98% (HPLC)
Molecular Weight:	337.37

View Full Technical Details for Talampanel

Technical Data
Citations

Biological Activity for Talampanel

Talampanel is a non-competitive AMPA/kainate receptor antagonist that displays 2.3-3-fold more potent activity than GYKI 52466 (Cat. No. 1454). Potentiates the anticonvulsive activity of antiepileptic drugs in animal models of seizures. Orally active.

Compound Libraries for Talampanel

Talampanel is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Talampanel

M. Wt	337.37
Formula	C₁₉H₁₉N₃O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	161832-65-1
PubChem ID	164509
InChi Key	JACAAXNEHGBPOQ-LLVKDONJSA-N
Smiles	NC(C=C4)=CC=C4C1=NN(C(C)=O)[C@H](C)CC2=C1C=C(OCO3)C3=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Talampanel

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.74	100

Preparing Stock Solutions for Talampanel

The following data is based on the product molecular weight 337.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.82 mL	29.64 mL
5 mM	0.59 mL	2.96 mL	5.93 mL
10 mM	0.30 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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References for Talampanel

References are publications that support the biological activity of the product.

Borowicz The AMPA/kainate receptor antagonist, LY 300164, increases the anticonvulsant effects of D.pam. Naunyn-Schmied.Arch.Pharmacol. 2000 PMID: 10882038
Belayev Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after traumatic brain injury in rats. J.Neurotrauma 2001 PMID: 11686490
Czuczwar LY 300164, a novel antagonist of AMPA/kainate receptors, potentiates the anticonvulsive activity of antiepileptic drugs. Eur.J.Pharmacol. 1998 PMID: 9832379