Tandospirone hydrochloride

Name: Tandospirone hydrochloride
Brand: Tocris Bioscience
SKU: 2854

Tocris Bioscience, part of Bio-Techne | Catalog # 2854

Citations (2)

COA / SDS

Selective 5-HT1A partial agonist

Key Product Details

Description:	Selective 5-HT_1A partial agonist
Alternative Names:	SM-3997
Chemical Name:	(3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	419.95

View Full Technical Details for Tandospirone hydrochloride

Technical Data
Citations

Biological Activity for Tandospirone hydrochloride

Tandospirone hydrochloride is a 5-HT_1A receptor partial agonist (K_i = 27 nM) that displays selectivity over 5-HT₂, 5-HT_1C, α₁, α₂, D₁ and D₂ receptors (K_i values ranging from 1300 - 41000 nM). Inactive at 5-HT uptake sites, 5-HT_1B, β-adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity.

Technical Data for Tandospirone hydrochloride

M. Wt	419.95
Formula	C₂₁H₂₉N₅O₂.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	99095-10-0
PubChem ID	13422623
InChi Key	ACVFJYKNBOHIMH-DPFKZJTMSA-N
Smiles	[H][C@]13[C@](C(N(CCCCN4CCN(C5=NC=CC=N5)CC4)C3=O)=O)([H])[C@@H]2CC[C@H]1C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tandospirone hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.99	100
	water	41.99	100

Preparing Stock Solutions for Tandospirone hydrochloride

The following data is based on the product molecular weight 419.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.91 mL	23.81 mL
5 mM	0.48 mL	2.38 mL	4.76 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for Tandospirone hydrochloride

References are publications that support the biological activity of the product.

Pollard Effects of tandospirone in three behavioral tests for anxiolytics. Eur.J.Pharmacol. 1992 PMID: 1358655
Matsubara Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-DArgic systems in rats with unilateral 6-hydroxyDA-generated lesions. Brain Res. 2006 PMID: 16884702
Hamik Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol.Psychiatry 1990 PMID: 1974152