TAT-cyclo-CLLFVY

Name: TAT-cyclo-CLLFVY
Brand: Tocris Bioscience
SKU: 5582

Tocris Bioscience, part of Bio-Techne | Catalog # 5582

Citations (6)

COA / SDS

Selective HIF-1 dimerization inhibitor

Key Product Details

Description:	Selective HIF-1 dimerization inhibitor
Purity:	≥95% (HPLC)
Molecular Weight:	2559.1

View Full Technical Details for TAT-cyclo-CLLFVY

Technical Data
Citations

Biological Activity for TAT-cyclo-CLLFVY

TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC₅₀ = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.

Technical Data for TAT-cyclo-CLLFVY

M. Wt	2559.1
Formula	C₁₁₁H₁₈₈N₄₂O₂₄S₂
Single Letter Sequence	CLLFVY CGRKKRRQRRRPPQ* (Modifications: Lactam bridge: Cys-1 to Tyr-6), Disulfide bridge: 1-1*)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1446322-66-2
PubChem ID	72192490
InChi Key	AWUUHEHYNQGEFC-XLZVTALKSA-N
Smiles	[H]N[C@@H](CSSC[C@@H]1N([H])C(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TAT-cyclo-CLLFVY

Solubility

Soluble to 1mg/ml in water

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for TAT-cyclo-CLLFVY

References are publications that support the biological activity of the product.

Miranda A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J.Am.Chem.Soc. 2013 PMID: 23796364