TC-FPR 43

Name: TC-FPR 43
Brand: Tocris Bioscience
SKU: 4624

Tocris Bioscience, part of Bio-Techne | Catalog # 4624

Citations (2)

COA / SDS

Potent FPR2 agonist

Key Product Details

Description:	Potent FPR2 agonist
Chemical Name:	N-(4-Chlorophenyl)-N-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea
Purity:	≥98% (HPLC)
Molecular Weight:	384.86

View Full Technical Details for TC-FPR 43

Technical Data
Citations

Biological Activity for TC-FPR 43

TC-FPR 43 is a potent formyl peptide receptor 2 (FPR2) agonist (EC₅₀ = 44 nM). Inhibits fMLP- and IL-8-induced neutrophil migration. Suppresses inflammation in a mouse model of acute inflammation. Orally bioavailable.

Compound Libraries for TC-FPR 43

TC-FPR 43 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TC-FPR 43

M. Wt	384.86
Formula	C₂₀H₂₁ClN₄O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	903895-98-7
PubChem ID	24776341
InChi Key	PAEBEUZTAPIOIO-UHFFFAOYSA-N
Smiles	CC(C)C1=C(NC(NC3=CC=C(Cl)C=C3)=O)C(N(C2=CC=CC=C2)N1C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC-FPR 43

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	38.49	100

Preparing Stock Solutions for TC-FPR 43

The following data is based on the product molecular weight 384.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.60 mL	12.99 mL	25.98 mL
5 mM	0.52 mL	2.60 mL	5.20 mL
10 mM	0.26 mL	1.30 mL	2.60 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for TC-FPR 43

References are publications that support the biological activity of the product.

Bürli Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Bioorg.Med.Chem.Lett. 2006 PMID: 16697190
Forsman Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library. Biochem.Pharmacol. 2011 PMID: 21095183
Dufton Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. J.Immunol. 2010 PMID: 20107188