TC JL 37

Name: TC JL 37
Brand: Tocris Bioscience
SKU: 6125

Tocris Bioscience, part of Bio-Techne | Catalog # 6125

Citations (1)

COA / SDS

Potent TYK2 inhibitor

Key Product Details

Description:	Potent TYK2 inhibitor
Chemical Name:	2-Chloro-4-cyano-6-fluoro-N-[2-[[[(1R,2R)-2-fluorocyclopropyl]carbonyl]amino]-4-pyridinyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	376.74

View Full Technical Details for TC JL 37

Technical Data
Citations

Biological Activity for TC JL 37

TC JL 37 is a potent inhibitor of tyrosine kinase 2 (TYK2, K_i = 1.6 nM). Shows some selectivity for TYK2 over JAK1/2/3. Inhibits IFNγ production in vivo in mice. Orally bioavailable.

Compound Libraries for TC JL 37

TC JL 37 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for TC JL 37

M. Wt	376.74
Formula	C₁₇H₁₁ClF₂N₄O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1258294-34-6
PubChem ID	56934550
InChi Key	NKALKXMQBFLGQI-CMPLNLGQSA-N
Smiles	F[C@@H]1C[C@@H]1C(NC2=CC(NC(C3=C(C=C(C#N)C=C3F)Cl)=O)=CC=N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC JL 37

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.67	100

Preparing Stock Solutions for TC JL 37

The following data is based on the product molecular weight 376.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.65 mL	13.27 mL	26.54 mL
5 mM	0.53 mL	2.65 mL	5.31 mL
10 mM	0.27 mL	1.33 mL	2.65 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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References for TC JL 37

References are publications that support the biological activity of the product.

Liang Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors. J.Med.Chem. 2013 PMID: 23668484