TC NTR1 17

Name: TC NTR1 17
Brand: Tocris Bioscience
SKU: 5087

Tocris Bioscience, part of Bio-Techne | Catalog # 5087

COA / SDS

Selective NTS1 partial agonist

Key Product Details

Description:	Selective NTS₁ partial agonist
Alternative Names:	ML 301 analog
Chemical Name:	N-[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]-L-leucine
Purity:	≥99% (HPLC)
Molecular Weight:	522.98

View Full Technical Details for TC NTR1 17

Technical Data
Citations

Biological Activity for TC NTR1 17

TC NTR1 17 is a non-peptide neurotensin receptor 1 (NTS₁) partial agonist (EC₅₀ <15.6 nM and E_max = 63% of neurotensin response in Ca²⁺ mobilization assay). Exhibits over 50-fold selectivity for NTS₁ over NTS₂ and GPR35.

Compound Libraries for TC NTR1 17

TC NTR1 17 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TC NTR1 17

M. Wt	522.98
Formula	C₂₇H₂₇ClN₄O₅
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1146757-96-1
PubChem ID	44157038
InChi Key	ZQUSYVORYNBGLG-FQEVSTJZSA-N
Smiles	O=C(N[C@@H](CC(C)C)C(O)=O)C2=NN(C(C3=C(OC)C=CC=C3OC)=C2)C1=C(C=CC(Cl)=C4)C4=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC NTR1 17

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	52.3	100
	1eq. NaOH	26.15	50

Preparing Stock Solutions for TC NTR1 17

The following data is based on the product molecular weight 522.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.91 mL	9.56 mL	19.12 mL
5 mM	0.38 mL	1.91 mL	3.82 mL
10 mM	0.19 mL	0.96 mL	1.91 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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References for TC NTR1 17

References are publications that support the biological activity of the product.

Hershberger Imidazole-derived agonists for the neurotensin 1 receptor. Bioorg.Med.Chem.Lett. 2014 PMID: 24332089