TC-S 7001

Name: TC-S 7001
Brand: Tocris Bioscience
SKU: 4961

Tocris Bioscience, part of Bio-Techne | Catalog # 4961

Citations (3)

COA / SDS

Potent and highly selective ROCK inhibitor; orally active

Key Product Details

Description:	Potent and highly selective ROCK inhibitor; orally active
Alternative Names:	Azaindole-1,BAY-549
Chemical Name:	6-Chloro-N⁴-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine
Purity:	≥98% (HPLC)
Molecular Weight:	402.79

View Full Technical Details for TC-S 7001

Technical Data
Citations

Biological Activity for TC-S 7001

TC-S 7001 (also known as BAY-549) is a potent and highly selective ROCK inhibitor (IC₅₀ values are 0.6 and 1.1 nM for human ROCK1 and ROCK2, respectively), which exhibits >200-fold selectivity over TRK and FLT3 receptors, and >900-fold selectivity over a panel of other kinases and cardiovascular relevent enzymes and receptors. TC-S 7001 reduces blood pressure in normotensive and hypertensive rats, and is orally active.

External Portal Information

Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of TC-S 7001 (BAY 549) is reviewed on chemicalprobes.org and the SGC website.

Technical Data for TC-S 7001

M. Wt	402.79
Formula	C₁₈H₁₃ClF₂N₆O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	867017-68-3
PubChem ID	11524200
InChi Key	NRSGWEVTVGZDFC-UHFFFAOYSA-N
Smiles	ClC1=CC(NC2=CC(F)=C(OC3=C(C(C)=CN4)C4=NC=C3)C(F)=C2)=NC(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC-S 7001

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.28	100
	ethanol	40.28	100

Preparing Stock Solutions for TC-S 7001

The following data is based on the product molecular weight 402.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.48 mL	12.41 mL	24.83 mL
5 mM	0.50 mL	2.48 mL	4.97 mL
10 mM	0.25 mL	1.24 mL	2.48 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for TC-S 7001

References are publications that support the biological activity of the product.

Dahal Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension. Eur.Resp.J. 2010 PMID: 20530035
Kast Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase. Br.J.Pharmacol. 2007 PMID: 17934515