TCS 2314

Name: TCS 2314
Brand: Tocris Bioscience
SKU: 3900

Tocris Bioscience, part of Bio-Techne | Catalog # 3900

Citations (3)

COA / SDS

α4β1 (VLA-4) antagonist

Key Product Details

Chemical Name:	1-[[(3S)-4-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acety]l-3-morpholinyl]carbonyl]-4-piperidinediacetic acid
Purity:	≥98%
Molecular Weight:	522.59 kDa

View Full Technical Details for TCS 2314

Technical Data
Citations

Biological Activity for TCS 2314

TCS 2314 is an integrin very late antigen-4 (VLA-4; α₄β₁) antagonist (IC₅₀ = 4.4 nM). Blocks the activation of inflammatory cells.

Technical Data for TCS 2314

M. Wt	522.59 kDa
Formula	C₂₈H₃₄N₄O₆
Storage	Store at RT
Purity	≥98%
CAS Number	317353-73-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TCS 2314

Solubility

Soluble Soluble to 100 mM in DMSO and to 50 mM in ethanol

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References for TCS 2314

References are publications that support the biological activity of the product.

Muro et al. Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J.Med.Chem., 2009;52:7974 PMID: 19891440