TCS OX2 29

Name: TCS OX2 29
Brand: Tocris Bioscience
SKU: 3371

Tocris Bioscience, part of Bio-Techne | Catalog # 3371

Citations (59)

COA / SDS

Potent and selective OX2 antagonist

Key Product Details

Description:	Potent and selective OX₂ antagonist
Chemical Name:	(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	433.97

View Full Technical Details for TCS OX2 29

Technical Data
Citations

Biological Activity for TCS OX2 29

TCS OX2 29 is a potent and selective OX₂ receptor antagonist (IC₅₀ = 40 nM). Displays >250-fold selectivity for OX₂ over OX₁ and a range of receptors, ion channels and transporters. Inhibits orexin A induced IP₃ accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX₂ receptor.

Compound Libraries for TCS OX2 29

TCS OX2 29 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TCS OX2 29

M. Wt	433.97
Formula	C₂₃H₃₁N₃O₃.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	1610882-30-8
PubChem ID	53302033
InChi Key	NHKNHFJTMINMBP-ZMBIFBSDSA-N
Smiles	C[C@@](C)(C)[C@H](NCC3=CC=NC=C3)C(N(C2)CCC1=C2C=C(OC)C(OC)=C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TCS OX2 29

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	43.4	100
	DMSO	10.85	25

Preparing Stock Solutions for TCS OX2 29

The following data is based on the product molecular weight 433.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.30 mL	11.52 mL	23.04 mL
5 mM	0.46 mL	2.30 mL	4.61 mL
10 mM	0.23 mL	1.15 mL	2.30 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for TCS OX2 29

References are publications that support the biological activity of the product.

Mould Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. Br.J.Pharmacol. 2014 PMID: 23692283
Hirose N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: The first orexin-2 receptor selective non-peptidic antagonist. Bioorg.Med.Chem.Lett. 2003 PMID: 14643355