TDI 11861

Name: TDI 11861
Brand: Tocris Bioscience
SKU: 8036

Tocris Bioscience, part of Bio-Techne | Catalog # 8036

COA / SDS

Soluble adenylyl cyclase inhibitor

Key Product Details

Description:	Soluble adenylyl cyclase inhibitor
Chemical Name:	(3R)-4-[2-[2-[[3-(2-Amino-6-chloro-4-pyrimidinyl)-1-(difluoromethyl)-1H-pyrazol-4-yl]methyl]phenoxy]ethyl]-3-morpholinemethanol
Purity:	≥98% (HPLC)
Molecular Weight:	494.93

View Full Technical Details for TDI 11861

Technical Data
Citations

Biological Activity for TDI 11861

TDI 11861 is a potent and selective soluble adenylyl cyclase (sAC) inhibitor (IC₅₀ values are 3.3 nM and 5.5 nM in biochemical and cellular assays, respectively; K_d = 1.4 nM). Inhibits cellular sAC-specific cAMP accumulation (IC₅₀ = 7 nM) and blocks sperm capacitation in vitro. Cell permeable, not cytotoxic and suitable for both in vivo and in vitro use.

Licensing Information

Sold under license from Cornell University

Technical Data for TDI 11861

M. Wt	494.93
Formula	C₂₂H₂₅ClF₂N₆O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2857049-72-8
PubChem ID	166101565
InChi Key	XVGSKZXXLKUEIO-MRXNPFEDSA-N
Smiles	FC(F)N1N=C(C2=NC(N)=NC(Cl)=C2)C(CC3=C(C=CC=C3)OCCN4[C@@H](COCC4)CO)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TDI 11861

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	49.49	100
	ethanol	49.49	100

Preparing Stock Solutions for TDI 11861

The following data is based on the product molecular weight 494.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.02 mL	10.10 mL	20.20 mL
5 mM	0.40 mL	2.02 mL	4.04 mL
10 mM	0.20 mL	1.01 mL	2.02 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for TDI 11861

References are publications that support the biological activity of the product.

Balbach On-demand male contraception via acute inhibition of soluble adenylyl cyclase. Nat.Commun. 2023 PMID: 36788210
Miller Design, synthesis, and pharmacological evaluation of second-generation soluble adenylyl cyclase (sAC, ADCY10) inhibitors with slow dissociation rates. J.Med.Chem. 2022 PMID: 36346696