Terbinafine hydrochloride

Name: Terbinafine hydrochloride
Brand: Tocris Bioscience
SKU: 6484

Tocris Bioscience, part of Bio-Techne | Catalog # 6484

Citations (1)

COA / SDS

Selective K2P9.1 (TASK-3) activator; also inhibits fungal squalene epoxidase

Key Product Details

Chemical Name:	N-[(2E)-6,6-Dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine hydrochloride
Purity:	≥98%

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Technical Data
Citations

Biological Activity for Terbinafine hydrochloride

Terbinafine hydrochloride is a selective TASK3 activator (pEC₅₀ = 6.2). Exhibits >10-fold selectivity for TASK3 over TREK2, TRESK, THIK1 and TASK2. Also inhibits TWIK1 (pIC₅₀ = 5.69). Also antifungal; inhibits fungal sterol biosynthesis by inhibition of squalene epoxidase.

Technical Data for Terbinafine hydrochloride

Formula	C₂₁H₂₅N.HCl
Storage	Store at +4°C
Purity	≥98%
CAS Number	78628-80-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Terbinafine hydrochloride

Solubility

Soluble Soluble to 100 mM in DMSO and to 10 mM in water with gentle warming

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References for Terbinafine hydrochloride

References are publications that support the biological activity of the product.

Petranyi et al. Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. Science, 1984;224:1239 PMID: 6547247
Wright et al. Terbinafine is a novel and selective activator of the two-pore domain potassium channel TASK3. Biochem.Biophys.Res.Commun., 2017;493:444 PMID: 28882594

Terbinafine hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 6484

Key Product Details

Biological Activity for Terbinafine hydrochloride

Technical Data for Terbinafine hydrochloride

Solubility for Terbinafine hydrochloride

Dilution Calculator

Reconstitution Calculator

References for Terbinafine hydrochloride

Product Documents for Terbinafine hydrochloride

COA

Certificate of Analysis

SDS

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