Tetrabenazine

Name: Tetrabenazine
Brand: Tocris Bioscience
SKU: 2175

Tocris Bioscience, part of Bio-Techne | Catalog # 2175

(1)

Citations (18)

COA / SDS

Potent inhibitor of vesicular monoamine transport

Key Product Details

Chemical Name:	(3R,11bR)-rel-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one
Purity:	≥98%
Molecular Weight:	317.2 kDa

View Full Technical Details for Tetrabenazine

Technical Data
Citations / Reviews (1)

Biological Activity for Tetrabenazine

Tetrabenazine is an inhibitor of vesicular monoamine transport with a 10-fold selectivity for the VMAT2 transporter over VMAT1 (IC₅₀ values = 0.3 μM and 3.4 μM, respectively). Tetrabenazine blocks D₂ receptors and dopamine uptake (IC₅₀ = 0.12 μM) and inhibits serotonin transport by VMAT2 (IC₅₀ = 300 nM). In an animal model of Huntington's disease, Tetrabenazine prevents the decline in motor control and reduces loss of striatal neurons. Tetrabenazine increases cFos expression in the thalamus and hippocampus, reduces brain connectivity and spontaneous locomotion and also causes behavioral depression.

Technical Data for Tetrabenazine

M. Wt	317.2 kDa
Formula	C₁₉H₂₇NO₃
Storage	Store at +4°C
Purity	≥98%
CAS Number	58-46-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tetrabenazine

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Tetrabenazine

References are publications that support the biological activity of the product.

Reches et al. Tetrabenazine, an amine-depleting drug, also blocks DA receptors in rat brain. J.Pharmacol.Exp.Ther, 1983;225:515 PMID: 6864517
Pettibone et al. Tetrabenazine-induced depletion of brain monoamines: characterisation and interaction with selected antidepressants. Eur.J.Pharmacol., 1984;102:425 PMID: 6489435
Scherman et al. Characterisation of the monoamine carrier of chromaffin granule membrane by binding of [2-³H]dihydrotetrabenazine. Proc.Natl.Acad.Sci.USA, 1983;80:584
Peter et al. Chimeric vesicular monoamine transporters identify structural domains that influence substrate affinity and sensitivity to tetraben. J.Biol.Chem., 1996;271:2979 PMID: 8621690