TFM-4AS-1

Name: TFM-4AS-1
Brand: Tocris Bioscience
SKU: 3813

Tocris Bioscience, part of Bio-Techne | Catalog # 3813

Citations (1)

COA / SDS

Selective androgen receptor modulator (SARM)

Key Product Details

Description:	Selective androgen receptor modulator (SARM)
Chemical Name:	(1S,3aS,3bS,5aR,9aR,9bS,11aS)-6,9a,11a-Trimethyl-7-oxo-N-[2-(trifluoromethyl)phenyl]-2,3,3a,3b,4,5,5a,9b,10,11-decahydro-1H-indeno[5,4-f]quinoline-1-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	474.56

View Full Technical Details for TFM-4AS-1

Technical Data
Citations

Biological Activity for TFM-4AS-1

TFM-4AS-1 is a potent selective androgen receptor modulator (SARM) (IC₅₀ = 30 nM). Steroidal compound. Exhibits limited effects on reproductive tissues and sebaceous glands; does not repress AP-1-sensitive MMP-1 reporter. Inhibits 5α-reductase type I and II (IC₅₀ values are 2 and 3 nM respectively).

Technical Data for TFM-4AS-1

M. Wt	474.56
Formula	C₂₇H₃₃F₃N₂O₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	188589-61-9
PubChem ID	10277123
InChi Key	YFBLEKKYWFJKBP-JZFZSVFHSA-N
Smiles	O=C1C=C[C@@]2(C)[C@](CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4[C@@](NC5=C(C(F)(F)F)C=CC=C5)=O)([H])N1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TFM-4AS-1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	4.75	10
	ethanol	4.75	10

Preparing Stock Solutions for TFM-4AS-1

The following data is based on the product molecular weight 474.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.07 mL	105.36 mL	210.72 mL
0.5 mM	4.21 mL	21.07 mL	42.14 mL
1 mM	2.11 mL	10.54 mL	21.07 mL
5 mM	0.42 mL	2.11 mL	4.21 mL

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References for TFM-4AS-1

References are publications that support the biological activity of the product.

Schmidt Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands. J.Biol.Chem. 2009 PMID: 19846549