TH 5487

Name: TH 5487
Brand: Tocris Bioscience
SKU: 6749

Tocris Bioscience, part of Bio-Techne | Catalog # 6749

Citations (4)

COA / SDS

Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor

Key Product Details

Description:	Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor
Chemical Name:	4-(4-Bromo-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-N-(4-iodophenyl)-1-piperidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	541.18

View Full Technical Details for TH 5487

Technical Data
Citations

Biological Activity for TH 5487

TH 5487 is a selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC₅₀ = 342 nM). Selective for OGG1 over other base excision repair enzymes. Inhibits OGG1 binding to 8-oxoG in DNA and suppresses proinflammatory gene expression in TNF-α stimulated lung epithelial cells in vitro. Also inhibits proinflamatory gene expression and neutrophil recruitment in TNF-α-challenged mouse lungs in vivo.

Licensing Information

Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.

Technical Data for TH 5487

M. Wt	541.18
Formula	C₁₉H₁₈BrIN₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2304947-71-3
PubChem ID	137321164
InChi Key	FZLKVWWPFOLPKF-UHFFFAOYSA-N
Smiles	O=C(NC1=CC=C(I)C=C1)N(CC2)CCC2N(C3=CC=CC(Br)=C3N4)C4=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TH 5487

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	54.12	100

Preparing Stock Solutions for TH 5487

The following data is based on the product molecular weight 541.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.85 mL	9.24 mL	18.48 mL
5 mM	0.37 mL	1.85 mL	3.70 mL
10 mM	0.18 mL	0.92 mL	1.85 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

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References for TH 5487

References are publications that support the biological activity of the product.

Visnes Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science 2018 PMID: 30442810