Thalidomide

Name: Thalidomide
Brand: Tocris Bioscience
SKU: 0652

Tocris Bioscience, part of Bio-Techne | Catalog # 0652

Citations (46)

COA / SDS

Binds cereblon; also TNF-α synthesis inhibitor

Key Product Details

Description:	Binds cereblon; also TNF-α synthesis inhibitor
Chemical Name:	N-(2,6-dioxo-3-piperidinyl)phthalimide
Purity:	≥99% (HPLC)
Molecular Weight:	258.23

View Full Technical Details for Thalidomide

Technical Data
Citations

Biological Activity for Thalidomide

Thalidomide is a selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Anti-inflammatory; promotes T-cell activation. Predicted to reduce cytokine release in SARS-CoV-2 infection. Also binds cereblon, inhibiting ubiquitin ligase activity. Teratogenic and sedative-hypnotic. Promotes degradation of transcription factor SALL4.

Technical Data for Thalidomide

M. Wt	258.23
Formula	C₁₃H₁₀N₂O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	50-35-1
PubChem ID	5426
InChi Key	UEJJHQNACJXSKW-UHFFFAOYSA-N
Smiles	O=C1N(C2CCC(=O)NC2=O)C(=O)C2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Thalidomide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	6.46	25

Preparing Stock Solutions for Thalidomide

The following data is based on the product molecular weight 258.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	15.49 mL	77.45 mL	154.90 mL
1.25 mM	3.10 mL	15.49 mL	30.98 mL
2.5 mM	1.55 mL	7.75 mL	15.49 mL
12.5 mM	0.31 mL	1.55 mL	3.10 mL

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Reconstitution Calculator

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References for Thalidomide

References are publications that support the biological activity of the product.

Li Network bioinformatics analysis provides insight into drug repurposing for COVID-2019. Med.Drug Discov. 2021 PMID: 33817623
Ito Identification of a primary target of Thal. teratogenicity. Science 2010 PMID: 20223979
Donovan Thal. promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome. Elife 2018 PMID: 30067223
Sampaio Thal. selectively inhibits tumor necrosis factor α production by stimulated human monocytes. J.Exp.Med. 1991 PMID: 1997652
Zhang Thal. influences growth and vasculogenic mimicry channel formation in melanoma. J.Exp.Clin.Cancer Res. 2008 PMID: 18983651
Makonkawkeyoon Thal. inhibits the replication of human-immunodeficiency-virus type 1. Proc.Natl.Acad.Sci.U.S.A. 1993 PMID: 8327469
Kanbayashi Thal., a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy. Neuroreport 1996 PMID: 8905685
Boireau Thal. reduces MPTP-induced decrease in striatal DA levels in mice. Neurosci.Lett. 1997 PMID: 9364513

Product Documents for Thalidomide

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Thalidomide, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov