THDOC

Name: THDOC
Brand: Tocris Bioscience
SKU: 6334

Tocris Bioscience, part of Bio-Techne | Catalog # 6334

Citations (9)

COA / SDS

Positive modulator of GABAA receptors; endogenous neurosteroid

Key Product Details

Chemical Name:	(3α,5α)-3,21-Dihydroxypregnan-20-one
Purity:	≥95%

View Full Technical Details for THDOC

Technical Data
Citations

Biological Activity for THDOC

THDOC is a positive modulator of GABA_A receptors. Potentiates neuronal response to low concentrations of GABA at α4β1δ GABA_A receptors in vitro. Endogenous neurosteroid.

Technical Data for THDOC

Formula	C₂₁H₃₄O₃
Storage	Store at RT
Purity	≥95%
CAS Number	567-02-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for THDOC

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for THDOC

References are publications that support the biological activity of the product.

Villumsen et al. Pharmacological characterisation of murine α4β1δ GABA_A receptors expressed in Xenopus oocytes. BMC.Neurosci., 2015;16 PMID: 25887256
Adams et al. Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABA_A receptors. Neuropharmacology., 2015;88:63 PMID: 25278033

THDOC

Tocris Bioscience, part of Bio-Techne | Catalog # 6334

Key Product Details

Biological Activity for THDOC

Technical Data for THDOC

Solubility for THDOC

Dilution Calculator

Reconstitution Calculator

References for THDOC

Product Documents for THDOC

COA

Certificate of Analysis

SDS

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