THDOC

Name: THDOC
Brand: Tocris Bioscience
SKU: 6334

Tocris Bioscience, part of Bio-Techne | Catalog # 6334

Citations (9)

COA / SDS

Positive modulator of GABAA receptors; endogenous neurosteroid

Key Product Details

Description:	Positive modulator of GABA_A receptors; endogenous neurosteroid
Chemical Name:	(3α,5α)-3,21-Dihydroxypregnan-20-one
Purity:	≥95% (HPLC)
Molecular Weight:	334.49

View Full Technical Details for THDOC

Technical Data
Citations

Biological Activity for THDOC

THDOC is a positive modulator of GABA_A receptors. Potentiates neuronal response to low concentrations of GABA at α4β1δ GABA_A receptors in vitro. Endogenous neurosteroid.

Technical Data for THDOC

M. Wt	334.49
Formula	C₂₁H₃₄O₃
Storage	Store at RT
Purity	≥95% (HPLC)
CAS Number	567-02-2
PubChem ID	91475
InChi Key	CYKYBWRSLLXBOW-SIDISFDHSA-N
Smiles	[H][C@@]12CC[C@@H]([C@]1(CC[C@]3([C@]2(CC[C@]4(C[C@@H](CC[C@]34C)O)[H])[H])[H])C)C(CO)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for THDOC

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.45	100
	ethanol	33.45	100

Preparing Stock Solutions for THDOC

The following data is based on the product molecular weight 334.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.99 mL	14.95 mL	29.90 mL
5 mM	0.60 mL	2.99 mL	5.98 mL
10 mM	0.30 mL	1.49 mL	2.99 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for THDOC

References are publications that support the biological activity of the product.

Adams Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABA_A receptors. Neuropharmacology. 2015 PMID: 25278033
Villumsen Pharmacological characterisation of murine α4β1δ GABA_A receptors expressed in Xenopus oocytes. BMC.Neurosci. 2015 PMID: 25887256