Thiamet G

Name: Thiamet G
Brand: Tocris Bioscience
SKU: 4390

Tocris Bioscience, part of Bio-Techne | Catalog # 4390

Citations (12)

COA / SDS

Potent O-GlcNAcase inhibitor

Key Product Details

Description:	Potent O-GlcNAcase inhibitor
Chemical Name:	(3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol
Molecular Weight:	248.3

View Full Technical Details for Thiamet G

Technical Data
Citations

Biological Activity for Thiamet G

Thiamet G is a potent, selective inhibitor of O-GlcNAcase (K_i = 21 nM for human O-GlcNAcase). Decreases the phosphorylation of tau protein in vivo. Promotes autophagy independently of mTOR pathway and reduces toxic protein species in mouse tauopathy model. Orally bioavailable and blood brain barrier permeable.

Technical Data for Thiamet G

M. Wt	248.3
Formula	C₉H₁₆N₂O₄S
Storage	Store at -20°C
CAS Number	1009816-48-1
PubChem ID	24808478
InChi Key	PPAIMZHKIXDJRN-FMDGEEDCSA-N
Smiles	CCNC2=N[C@]1([H])[C@@H](O)[C@H](O)[C@@H](CO)O[C@@]([H])1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Thiamet G

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	12.41	50

Preparing Stock Solutions for Thiamet G

The following data is based on the product molecular weight 248.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.05 mL	40.27 mL	80.55 mL
2.5 mM	1.61 mL	8.05 mL	16.11 mL
5 mM	0.81 mL	4.03 mL	8.05 mL
25 mM	0.16 mL	0.81 mL	1.61 mL

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References for Thiamet G

References are publications that support the biological activity of the product.

Zhu Pharmacological inhibition of O-GlcNAcase enhances autophagy in brain through an mTOR-independent pathway ACS Chem.Neurosci. 2018 PMID: 29460617
Yuzwa A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat.Chem.Biol. 2008 PMID: 18587388