Thioridazine hydrochloride

Name: Thioridazine hydrochloride
Brand: Tocris Bioscience
SKU: 3070

Tocris Bioscience, part of Bio-Techne | Catalog # 3070

Citations (6)

COA / SDS

Dopamine receptor antagonist; antipsychotic

Key Product Details

Description:	Dopamine receptor antagonist; antipsychotic
Chemical Name:	10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	407.04

View Full Technical Details for Thioridazine hydrochloride

Technical Data
Citations

Biological Activity for Thioridazine hydrochloride

Thioridazine hydrochloride is a dopamine receptor antagonist that displays antipsychotic activity. Exhibits anticancer activity in cervical, endometrial and breast cancer cells; triggers apoptosis by targeting the PI 3-K/Akt/mTOR/p70 S6K pathway. Induces G₁ cell cycle arrest. Selective inducer of cancer stem cell (CSC) differentiation.

Technical Data for Thioridazine hydrochloride

M. Wt	407.04
Formula	C₂₁H₂₆N₂S₂.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	130-61-0
PubChem ID	66062
InChi Key	NZFNXWQNBYZDAQ-UHFFFAOYSA-N
Smiles	CN(CCCC4)C4CCN2C3=C(C=CC(SC)=C3)SC1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Thioridazine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	30.53	75
	DMSO	40.7	100

Preparing Stock Solutions for Thioridazine hydrochloride

The following data is based on the product molecular weight 407.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.28 mL	24.57 mL
5 mM	0.49 mL	2.46 mL	4.91 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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References for Thioridazine hydrochloride

References are publications that support the biological activity of the product.

Kang Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. 2012 PMID: 22460505
Sachlos Identification of drugs including a DA receptor antagonist that selectively target cancer stem cells. Cell. 2012 PMID: 22632761