THIP hydrochloride

Name: THIP hydrochloride
Brand: Tocris Bioscience
SKU: 0807
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0807

(1)

Citations (15)

COA / SDS

GABAA agonist

Key Product Details

Description:	GABA_A agonist
Alternative Names:	Gaboxadol
Chemical Name:	4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	176.6

View Full Technical Details for THIP hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for THIP hydrochloride

THIP hydrochloride is a systemically active GABA_A receptor agonist and GABA_A-ρ receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.

Compound Libraries for THIP hydrochloride

THIP hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for THIP hydrochloride

M. Wt	176.6
Formula	C₆H₈N₂O₂.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	85118-33-8
PubChem ID	5702253
InChi Key	ZDZDSZQYRBZPNN-UHFFFAOYSA-N
Smiles	Cl.OC1=NOC2=C1CCNC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for THIP hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	17.66	100
	DMSO	17.66	100

Preparing Stock Solutions for THIP hydrochloride

The following data is based on the product molecular weight 176.6.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.66 mL	28.31 mL	56.63 mL
5 mM	1.13 mL	5.66 mL	11.33 mL
10 mM	0.57 mL	2.83 mL	5.66 mL
50 mM	0.11 mL	0.57 mL	1.13 mL

Molarity Calculator

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Reconstitution Calculator

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References for THIP hydrochloride

References are publications that support the biological activity of the product.

Krogsgaard-Larson Chemistry and pharmacology of the GABA antagonists THIP (Gaboxadol) and isoguvacine. Drugs Future.
Johnston GABA_C receptors: relatively simple transmitter-gated ion channels? TiPS 1996 PMID: 8885697
Krogsgaard-Larson 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity. J.Med.Chem. 1983 PMID: 6304315
Huckle Gaboxadol. Lundbeck/Merck Curr.Opin.Investig.Drugs 2004 PMID: 15298075