THIP hydrochloride

Name: THIP hydrochloride
Brand: Tocris Bioscience
SKU: 0807

Tocris Bioscience, part of Bio-Techne | Catalog # 0807

(1)

Citations (15)

COA / SDS

GABAA agonist

Key Product Details

Chemical Name:	4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride
Purity:	≥98%
Molecular Weight:	176.6 kDa

View Full Technical Details for THIP hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for THIP hydrochloride

THIP hydrochloride is a systemically active GABA_A receptor agonist and GABA_A-ρ receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.

Technical Data for THIP hydrochloride

M. Wt	176.6 kDa
Formula	C₆H₈N₂O₂.HCl
Storage	Store at RT
Purity	≥98%
CAS Number	85118-33-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for THIP hydrochloride

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

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References for THIP hydrochloride

References are publications that support the biological activity of the product.

Fox JT, Sakamuru S, Huang R High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. 2012 PMID: 22431602
Seifi M, Brown J, Mills J, Bhandari P, Belelli D, Lambert J, Rudolph U, Swinny J Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. , 2014;0(0):. 2014 PMID: 25080596
Johnston GABA_C receptors: relatively simple transmitter-gated ion channels? TiPS, 1996;17:319 PMID: 8885697
Krogsgaard-Larson 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity. J.Med.Chem., 1983;26:895 PMID: 6304315
Huckle Gaboxadol. Lundbeck/Merck Curr.Opin.Investig.Drugs, 2004;5:766 PMID: 15298075
Krogsgaard-Larson Chemistry and pharmacology of the GABA antagonists THIP (Gaboxadol) and isoguvacine. Drugs Future., 1984;9:597