THIQ

Tocris Bioscience, part of Bio-Techne | Catalog # 3032

(1)

Citations (15)

COA / SDS

Potent and selective MC4 receptor agonist

Key Product Details

Description:	Potent and selective MC₄ receptor agonist
Chemical Name:	N-[(1R)-1-[(4-Chlorophenyl)methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-trazol-1-ylmethyl)-1-piperidinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide
Purity:	≥95% (HPLC)
Molecular Weight:	589.17

View Full Technical Details for THIQ

Technical Data
Citations / Reviews (1)

Biological Activity for THIQ

THIQ is a potent and selective melanocortin 4 (MC₄) receptor agonist (IC₅₀ values are 1.2, 761 and 2067 nM for human MC₄, MC₃ and MC₁ receptors respectively). Enhances intracavernosal pressure and stimulates erectile activity in rats ex copula following systemic administration.

Technical Data for THIQ

M. Wt	589.17
Formula	C₃₃H₄₁ClN₆O₂
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	312637-48-2
PubChem ID	9938402
InChi Key	HLCHESOMJVGDSJ-LOYHVIPDSA-N
Smiles	O=[C@@]([C@H](NC([C@H]5CC(C=CC=C6)=C6CN5)=O)CC4=CC=C(Cl)C=C4)N1CCC(CN2N=CN=C2)(C3CCCCC3)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for THIQ

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	5.89	10

Preparing Stock Solutions for THIQ

The following data is based on the product molecular weight 589.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.97 mL	84.87 mL	169.73 mL
0.5 mM	3.39 mL	16.97 mL	33.95 mL
1 mM	1.70 mL	8.49 mL	16.97 mL
5 mM	0.34 mL	1.70 mL	3.39 mL

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References for THIQ

References are publications that support the biological activity of the product.

Martin Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula. Eur.J.Pharmacol. 2002 PMID: 12409007
Mutulis New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of "THIQ". J.Med.Chem. 2004 PMID: 15317471
Sebhat Design and pharmacology of N-[(3R)-1,2,3,4-Tetrahydroisoquinolinium-3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-methyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective melanocorti J.Med.Chem. 2002 PMID: 12361385