Tizanidine hydrochloride

Name: Tizanidine hydrochloride
Brand: Tocris Bioscience
SKU: 3609

Tocris Bioscience, part of Bio-Techne | Catalog # 3609

Citations (1)

COA / SDS

α2 agonist

Key Product Details

Chemical Name:	5-(Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride
Purity:	≥99%
Molecular Weight:	290.17 kDa

View Full Technical Details for Tizanidine hydrochloride

Technical Data
Citations

Biological Activity for Tizanidine hydrochloride

Tizanidine hydrochloride is an α₂-adrenergic receptor agonist. Antinociceptive upon epidural administration in rats (IC₅₀ = 48 nM). Also binds to imidazoline receptor.

Technical Data for Tizanidine hydrochloride

M. Wt	290.17 kDa
Formula	C₉H₈ClN₅S.HCl
Storage	Desiccate at RT
Purity	≥99%
CAS Number	64461-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tizanidine hydrochloride

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

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References for Tizanidine hydrochloride

References are publications that support the biological activity of the product.

Asano et al. Antinociception by epidural and systemic α₂-adrenoceptor agonists and their binding affinity in rat spinal cord and brain. Anesth.Analg., 2000;90:400 PMID: 10648329
Piletz et al. Autoradiographic comparison of [³H]-Clonidine binding to non-adrenergic sites and α₂-adrenergic receptors in human brain. Neuropsychopharmacology, 2000;23:697 PMID: 11063925