TL 13-27

Name: TL 13-27
Brand: Tocris Bioscience
SKU: 6525

Tocris Bioscience, part of Bio-Techne | Catalog # 6525

COA / SDS

Negative control for TL 12-186 (Cat. No. 6524)

Key Product Details

Description:	Negative control for TL 12-186 (Cat. No. 6524)
Chemical Name:	N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-4-yl)amino)acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	917.48

View Full Technical Details for TL 13-27

Technical Data
Citations

Biological Activity for TL 13-27

TL 13-27 is a negative control for TL 12-186 (Cat. No. 6524). Demonstrates no kinase degradation in vitro.

Technical Data for TL 13-27

M. Wt	917.48
Formula	C₄₄H₅₃ClN₁₀O₈S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2250025-90-0
PubChem ID	134812844
InChi Key	DOOUFCVVMSZNOA-UHFFFAOYSA-N
Smiles	O=C1C(CCCN1)N2C(C3=C(C2=O)C=CC=C3NCC(NCCOCCOCCN4CCN(CC4)C5=CC=C(C=C5)NC6=NC(NC7=C(C=CC=C7)S(=O)(C(C)C)=O)=C(C=N6)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TL 13-27

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	91.75	100

Preparing Stock Solutions for TL 13-27

The following data is based on the product molecular weight 917.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.09 mL	5.45 mL	10.90 mL
5 mM	0.22 mL	1.09 mL	2.18 mL
10 mM	0.11 mL	0.54 mL	1.09 mL
50 mM	0.02 mL	0.11 mL	0.22 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for TL 13-27

References are publications that support the biological activity of the product.

Huang A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader. Cell Chem.Biol. 2018 PMID: 29129717