Torin 1

Biological Activity for Torin 1

Technical Data for Torin 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Torin 1

References for Torin 1

References are publications that support the biological activity of the product.

• JA Schwartz, KL Clayton, S Mujib, H Zhang, AK Rahman, J Liu, FY Yue, E Benko, C Kovacs, MA Ostrowski Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9 J. Immunol, 2017;0(0):. 2017 PMID: 28264968
• Jahn S, Law M, Corsino P, Davis B, Harrison J, Law B Signaling mechanisms that suppress the cytostatic actions of rapamycin. PLoS ONE, 2014;9(6):e99927. 2014 PMID: 24927123
• Bernard M, Dieude M, Yang B, Hamelin K, Underwood K, Hebert M Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF. Autophagy, 2014;10(12):2193-207. 2014 PMID: 25495560
• Taguchi, Keiko, Fujikawa, Nanako, Komatsu, Masaaki, Ishii, Tetsuro, Unno, Michiaki, Akaike, Takaaki, Motohashi, Hozumi, Yamamoto, Masayuki Keap1 degradation by autophagy for the maintenance of redox homeostasis. Proc Natl Acad Sci U S A, 2012;109(34):13561-6. 2012 PMID: 22872865
• Tholen M, Wolanski J, Stolze B, Chiabudini M, Gajda M, Bronsert P, Stickeler E, Rospert S, Reinheckel T Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression. J Biol Chem, 2015;290(25):15758-69. 2015 PMID: 25957406
• P Xie, Z Zheng, L Jiang, S Wu Penehyclidine effects the angiogenic potential of pulmonary microvascular endothelial cells Pulm Pharmacol Ther, 2019;0(0):. 2019 PMID: 30641132
• JM Park, M Seo, CH Jung, D Grunwald, M Stone, NM Otto, E Toso, Y Ahn, M Kyba, TJ Griffin, L Higgins, DH Kim ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction Autophagy, 2018;0(0):1-28. 2018 PMID: 29313410
• Su X, Yu Y, Zhong Y, Giannopoulou E, Hu X, Liu H, Cross J, Ratsch G, Rice C, Ivashkiv L Interferon-gamma regulates cellular metabolism and mRNA translation to potentiate macrophage activation. Nat Immunol, 2015;16(8):838-49. 2015 PMID: 26147685
• I Kelsey, M Zbinden, V Byles, M Torrence, BD Manning mTORC1 suppresses PIM3 expression via miR-33 encoded by the SREBP loci Sci Rep, 2017;7(1):16112. 2017 PMID: 29170467
• Guerrero A, Iglesias C, Raguz S, Floridia E, Gil J, Pombo C, Zalvide J The cerebral cavernous malformation 3 gene is necessary for senescence induction. Aging Cell, 2015;14(2):274-83. 2015 PMID: 25655101
• S Vega-Rubin, S Pe¤a-Llopi, M Konda, J Brugarolas Multistep regulation of TFEB by MTORC1 Autophagy, 2017;0(0):0. 2017 PMID: 28055300
• Shi Y, Chen J, Karner C, Long F Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation. Proc Natl Acad Sci U S A, 2015;112(15):4678-83. 2015 PMID: 25825734
• G Figlia, C Norrmén, JA Pereira, D Gerber, U Suter Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system Elife, 2017;6(0):. 2017 PMID: 28880149
• F Gebauer, D Wicklein, M Tachezy, T Grob, D Steinemann, G Manukjan, G Göhring, B Schlegelbe, H Maar, JR Izbicki, M Bockhorn, U Schumacher Establishment and Characterization of a Pair of Patient-derived Human Non-small Cell Lung Cancer Cell Lines from a Primary Tumor and Corresponding Lymph Node Metastasis Anticancer Res, 2016;36(4):1507-18. 2016 PMID: 27069126
• Ando R, Shima H, Tamahara T, Sato Y, Watanabe-Matsui M, Kato H, Sax N, Motohashi H, Taguchi K, Yamamoto M, Nio M, Maeda T, Ochiai K, Muto A, Igarashi K The Transcription Factor Bach2 Is Phosphorylated at Multiple Sites in Murine B Cells but a Single Site Prevents Its Nuclear Localization. J Biol Chem, 2016;291(4):1826-40. 2016 PMID: 26620562
• Li, I-Hsun, Ma, Kuo-Hsin, Weng, Shao-Ju, Huang, Shiang-S, Liang, Chang-Mi, Huang, Yuahn-Si Autophagy activation is involved in 3,4-methylenedioxymethamphetamine ('ecstasy')--induced neurotoxicity in cultured cortical neurons. PLoS ONE, 2014;9(12):e116565. 2014 PMID: 25551657
• K Willén, JR Edgar, T Hasegawa, N Tanaka, CE Futter, GK Gouras A? accumulation causes MVB enlargement and is modelled by dominant negative VPS4A Mol Neurodegener, 2017;12(1):61. 2017 PMID: 28835279
• Li He Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism J Leukoc Biol, 2016;0(0):. 2016 PMID: 27312848
• M Mauro-Lizc, A López-Riva Glutamine metabolism regulates FLIP expression and sensitivity to TRAIL in triple-negative breast cancer cells Cell Death Dis, 2018;9(2):205. 2018 PMID: 29434187
• Thoreen CC, Kang SA, Chang JW et al. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem 2009-03-01 PMID: 19150980
• Galluzzi et al. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov., 2017; PMID: 28529316
• Guertin and Sabatini The pharmacology of mTOR inhibition. Sci.Signal., 2009;2:pe24 PMID: 19383975
• Peterson et al. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell., 2011;146:408 PMID: 21816276
• Liu et al. Discovery of 1-(4(-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. J.Med.Chem., 2010;53:7146 PMID: 20860370