Torin 1

Name: Torin 1
Brand: Tocris Bioscience
SKU: 4247
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4247

(2)

Citations (540)

COA / SDS

Potent and selective mTOR inhibitor

Key Product Details

Description:	Potent and selective mTOR inhibitor
Chemical Name:	1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
Purity:	≥98% (HPLC)
Molecular Weight:	607.62

View Full Technical Details for Torin 1

Technical Data
Citations / Reviews (2)

Biological Activity for Torin 1

Torin 1 is a potent and selective ATP-competitive mTOR inhibitor (IC₅₀ = 2 - 10 nM for mTORC1 and mTORC2). Torin 1 displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34. In HeLa cells, Torin 1 induces autophagy. Torin 1 impairs cell growth and proliferation by suppression of the rapamycin-resistant functions of mTORC1. In human monocytes and myeloid dendritic cells, Torin 1 prevents decreases the anti-inflammatory potency of glucocorticoids. In the human endocrine cell line BON, Torin 1 increases neurotensin secretion and gene expression through MEK/ERK/c-Jun pathway activation.

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Technical Data for Torin 1

M. Wt	607.62
Formula	C₃₅H₂₈F₃N₅O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1222998-36-8
PubChem ID	49836027
InChi Key	AKCRNFFTGXBONI-UHFFFAOYSA-N
Smiles	O=C(N5C6=CC(C(F)(F)F)=C(N7CCN(C(CC)=O)CC7)C=C6)C=CC2=C5C1=CC(C3=CN=C(C=CC=C4)C4=C3)=CC=C1N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Torin 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	0.61	1 with gentle warming

Preparing Stock Solutions for Torin 1

The following data is based on the product molecular weight 607.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.01 mM	164.58 mL	822.88 mL	1,645.77 mL
0.05 mM	32.92 mL	164.58 mL	329.15 mL
0.1 mM	16.46 mL	82.29 mL	164.58 mL
0.5 mM	3.29 mL	16.46 mL	32.92 mL

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References for Torin 1

References are publications that support the biological activity of the product.

Weichhart Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells. Blood 2011 PMID: 21368289
Li mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. Am.J.Physiol.Cell Physiol. 2011 PMID: 21508335
Galluzzi Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. 2017 PMID: 28529316
Peterson mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell. 2011 PMID: 21816276
Liu Discovery of 1-(4(-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. J.Med.Chem. 2010 PMID: 20860370
Thoreen An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J.Biol.Chem. 2009 PMID: 19150980
Guertin and Sabatini The pharmacology of mTOR inhibition. Sci.Signal. 2009 PMID: 19383975