Torin 2

Name: Torin 2
Brand: Tocris Bioscience
SKU: 4248
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4248

(1)

Citations (67)

COA / SDS

Potent and selective mTOR inhibitor

Key Product Details

Description:	Potent and selective mTOR inhibitor
Chemical Name:	9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
Purity:	≥98% (HPLC)
Molecular Weight:	432.4

View Full Technical Details for Torin 2

Technical Data
Citations / Reviews (1)

Biological Activity for Torin 2

Torin 2 is a potent and selective mTOR inhibitor (IC₅₀ = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC₅₀ values are 0.25 and 200 nM for mTOR and PI3K respectively). Activates autophagy. Orally available.

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Compound Libraries for Torin 2

Torin 2 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Torin 2

M. Wt	432.4
Formula	C₂₄H₁₅F₃N₄O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1223001-51-1
PubChem ID	51358113
InChi Key	GUXXEUUYCAYESJ-UHFFFAOYSA-N
Smiles	O=C(C=C3)N(C5=CC=CC(C(F)(F)F)=C5)C2=C3C=NC1=CC=C(C4=CC=C(N)N=C4)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Torin 2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	8.65	20

Preparing Stock Solutions for Torin 2

The following data is based on the product molecular weight 432.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.56 mL	57.82 mL	115.63 mL
1 mM	2.31 mL	11.56 mL	23.13 mL
2 mM	1.16 mL	5.78 mL	11.56 mL
10 mM	0.23 mL	1.16 mL	2.31 mL

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References for Torin 2

References are publications that support the biological activity of the product.

Simioni Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation. Oncotarget 2014 PMID: 25296981
Galluzzi Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. 2017 PMID: 28529316
Liu Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. J.Med.Chem. 2011 PMID: 21322566