Toyocamycin

Name: Toyocamycin
Brand: Tocris Bioscience
SKU: 5270

Tocris Bioscience, part of Bio-Techne | Catalog # 5270

(1)

Citations (2)

COA / SDS

Adenosine analog; antifungal antibiotic

Key Product Details

Chemical Name:	4-Amino-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
Purity:	≥98%

View Full Technical Details for Toyocamycin

Technical Data
Citations / Reviews (1)

Biological Activity for Toyocamycin

Toyocamycin is an adenosine analog; antifungal antibiotic. Inhibits RNA self-cleavage in HEK79 cells and PI 3-kinase activity in A431 epidermoid carcinoma cell membrane fractions. Also inhibits thapsigargin-induced XBP1-luciferase activation and induces apoptosis in multiple myeloma cell lines.

Technical Data for Toyocamycin

Formula	C₁₂H₁₃N₅O₄
Storage	Store at +4°C
Purity	≥98%
CAS Number	606-58-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Toyocamycin

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Toyocamycin

References are publications that support the biological activity of the product.

Ri et al. Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood.Cancer.J., 2012;2:e79 PMID: 22852048
Nishioka et al. Inhibition of phosphatidylinositol kinase by toyocamycin. J.Antibiot. (Tokyo)., 1990;43:1586 PMID: 2177464
Yen et al. Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA, 2006;12:797 PMID: 16556935

Toyocamycin

Tocris Bioscience, part of Bio-Techne | Catalog # 5270

Key Product Details

Biological Activity for Toyocamycin

Technical Data for Toyocamycin

Solubility for Toyocamycin

Dilution Calculator

Reconstitution Calculator

References for Toyocamycin

Product Documents for Toyocamycin

COA

Certificate of Analysis

SDS

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